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Tbio
UVRAG
UV radiation resistance-associated gene protein

Protein Summary
Description
Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:24056303). During autophagy acts as regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation of autophagosomes and endocytosis. Activates lipid kinase activity of PIK3C3. Involved in the regulation of degradative endocytic trafficking and cytokinesis, and in regulation of ATG9A transport from the Golgi to the autophagosome; the functions seems to implicate its association with PI3KC3-C2 (PubMed:16799551, PubMed:20643123, PubMed:24056303). Involved in maturation of autophagosomes and degradative endocytic trafficking indepe ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356136
  • ENSP00000348455
  • ENSG00000198382
  • ENST00000531818
  • ENSP00000434082
  • ENST00000532130
  • ENSP00000436270
  • ENST00000533454
  • ENSP00000431256

Symbol
  • p63
  • DHTX
  • VPS38
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
kinase perturbation
0.97
transcription factor binding site profile
0.92
drug perturbation
0.87
virus perturbation
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.37   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 336   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.37   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 336   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (110)
RUBCNL
Tbio
Novelty:  0.20019585
p_int:  1
Score:  0.635
Data Source:  BioPlex,STRINGDB
BECN1
Tbio
Novelty:  0.0003792
Score:  0.999
Data Source:  Reactome,STRINGDB
PIK3C3
Tchem
Family:  Kinase
Novelty:  0.00269825
Score:  0.998
Data Source:  Reactome,STRINGDB
PIK3R4
Tbio
Family:  Kinase
Novelty:  0.01412698
Score:  0.995
Data Source:  Reactome,STRINGDB
RUBCN
Tbio
Novelty:  0.03247565
Score:  0.987
Data Source:  STRINGDB
SH3GLB1
Tbio
Novelty:  0.0314974
Score:  0.982
Data Source:  STRINGDB
GABARAPL2
Tbio
Novelty:  0.0022546
Score:  0.973
Data Source:  STRINGDB
GABARAPL1
Tbio
Novelty:  0.00212657
Score:  0.973
Data Source:  STRINGDB
GABARAP
Tbio
Novelty:  0.00444901
Score:  0.965
Data Source:  STRINGDB
MAP1LC3A
Tbio
Novelty:  0.00301583
Score:  0.962
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Macroautophagy
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Macroautophagy
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (27)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
9
7
12
97.1
apolipoprotein A 1 measurement
2
3
3
95
hemoglobin measurement
3
3
3
83.6
vitamin D measurement
3
3
3
78.5
alkaline phosphatase measurement
2
2
1
5.8
70.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
12
97.1
apolipoprotein A 1 measurement
3
95
hemoglobin measurement
3
83.6
vitamin D measurement
3
78.5
alkaline phosphatase measurement
1
5.8
70.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
UV radiation resistance associated
VGNC:944
451430
Macaque
UV radiation resistance associated
696601
Mouse
MGI:1925860
78610
Rat
RGD:1589754
308846
Dog
UV radiation resistance associated
VGNC:48218
607998
Species
Name
OMA
EggNOG
Inparanoid
Chimp
UV radiation resistance associated
Macaque
UV radiation resistance associated
Mouse
Rat
Dog
UV radiation resistance associated
Publication Statistics
PubMed Score 90.37
PubMed score by year
PubTator Score 45.79
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title