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Tbio
DEC1
Deleted in esophageal cancer 1

Protein Summary
Description
Candidate tumor suppressor. The function of this gene is not known. This gene is located in a region commonly deleted in esophageal squamous cell carcinomas. Gene expression is reduced or absent in these carcinomas and thus this is a candidate tumor suppressor gene for esophageal squamous cell carcinomas. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000648722
  • ENSP00000497207
  • ENSG00000173077

Symbol
  • CTS9
  • CTS9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.64
cell line
0.51
biological term
0.45
disease
0.44
phenotype
0.42


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.81   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 4   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.81   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 4   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (17)
BHLHE40
Tbio
Family:  TF
Novelty:  0.01175662
Score:  0.949
Data Source:  STRINGDB
ARNTL
Tbio
Family:  TF
Novelty:  0.00102829
Score:  0.947
Data Source:  STRINGDB
CLOCK
Tbio
Family:  TF; Epigenetic
Novelty:  0.00159625
Score:  0.93
Data Source:  STRINGDB
NFIL3
Tbio
Family:  TF
Novelty:  0.00882074
Score:  0.669
Data Source:  STRINGDB
BHLHE41
Tbio
Family:  TF
Novelty:  0.01015053
Score:  0.599
Data Source:  STRINGDB
NPAS2
Tbio
Family:  TF
Novelty:  0.00728451
Score:  0.584
Data Source:  STRINGDB
CIPC
Tdark
Novelty:  0.02263148
Score:  0.519
Data Source:  STRINGDB
NONO
Tbio
Novelty:  0.00501502
Score:  0.519
Data Source:  STRINGDB
GSK3B
Tclin
Family:  Kinase
Novelty:  0.00095115
Score:  0.519
Data Source:  STRINGDB
CRY1
Tchem
Novelty:  0.00116593
Score:  0.492
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
8
8
0
1.4
97.6
2
3
0
1.3
94.8
3
4
0
1.1
93.5
eosinophil count
3
3
3
93.4
primary biliary cirrhosis
3
2
0
1.6
90
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.4
97.6
0
1.3
94.8
0
1.1
93.5
eosinophil count
3
93.4
primary biliary cirrhosis
0
1.6
90
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
deleted in esophageal cancer 1 [Source:HGNC Symbol;Acc:HGNC:23658]
Macaque
deleted in esophageal cancer 1
106993631
Species
Name
OMA
EggNOG
Inparanoid
Chimp
deleted in esophageal cancer 1 [Source:HGNC Symbol;Acc:HGNC:23658]
Macaque
deleted in esophageal cancer 1
Publication Statistics
PubMed Score 10.81
PubMed score by year
PubTator Score 525.04
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title