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Tbio
IMPACT
Protein IMPACT

Protein Summary
Description
Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis. Through its inhibitory action on EIF2AK4/GCN2, plays a role in differentiation of neuronal cells by stimulating neurite outgrowth.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000284202
  • ENSP00000284202
  • ENSG00000154059

Symbol
  • RWDD5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
protein domain
0.85
virus perturbation
0.83
transcription factor perturbation
0.8
kinase perturbation
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.63   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.63   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
0
5.4
0.6
diastolic blood pressure
1
1
0
5.4
0.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
0
5.4
0.6
diastolic blood pressure
0
5.4
0.6
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
impact RWD domain protein
VGNC:8870
455343
Macaque
impact RWD domain protein
707508
Mouse
MGI:1098233
16210
Rat
RGD:1591977
497198
Dog
impact RWD domain protein
VGNC:42008
490513
Species
Name
OMA
EggNOG
Inparanoid
Chimp
impact RWD domain protein
Macaque
impact RWD domain protein
Mouse
Rat
Dog
impact RWD domain protein
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9P2X3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (21)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (19)
1 – 10 of 19
CA10
Tbio
Family:  Enzyme
Novelty:  0.01053152
p_int:  0.999981766
p_ni:  0.000018206
p_wrong:  2.7e-8
Score:  0.228
Data Source:  BioPlex,STRINGDB
TGFA
Tbio
Novelty:  0.00216159
p_int:  0.921508777
p_ni:  0.000140862
p_wrong:  0.078350361
Data Source:  BioPlex
CRHBP
Tbio
Novelty:  0.00726484
p_int:  0.914563691
p_ni:  0.009277685
p_wrong:  0.076158624
Score:  0.297
Data Source:  BioPlex,STRINGDB
HRG
Tbio
Novelty:  0.0027048
p_int:  0.904619566
p_ni:  0.00020767
p_wrong:  0.095172764
Data Source:  BioPlex
GCN1
Tbio
Novelty:  0.02721216
Score:  0.76
Data Source:  STRINGDB
COPS5
Tchem
Novelty:  0.00406225
Score:  0.701
Data Source:  STRINGDB
LENG1
Tdark
Novelty:  1.81219077
Score:  0.673
Data Source:  STRINGDB
KARS
Tchem
Family:  Enzyme
Novelty:  0.00386511
Score:  0.64
Data Source:  STRINGDB
EIF2AK4
Tchem
Family:  Kinase
Novelty:  0.00241683
Score:  0.613
Data Source:  STRINGDB
RWDD1
Tbio
Novelty:  0.14946142
Score:  0.541
Data Source:  STRINGDB
Publication Statistics
PubMed Score  13.63

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer