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Tbio
B3GAT1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

Protein Summary
Description
Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group. The protein encoded by this gene is a member of the glucuronyltransferase gene family. These enzymes exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product functions as the key enzyme in a glucuronyl transfer reaction during the biosynthesis of the carbohydrate epitope HNK-1 (human natural killer-1, also known as CD57 and LEU7). Alternate transcriptional splice variant ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312527
  • ENSP00000307875
  • ENSG00000109956
  • ENST00000392580
  • ENSP00000376359
  • ENST00000524765
  • ENSP00000433847

Symbol
  • GLCATP
  • NK1
  • CD57
  • HNK1
  • LEU7
  • NK-1
  • GLCATP
  • GLCUATP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.69
virus perturbation
0.68
cellular component
0.67
biological term
0.62
pathway
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 837.16   (req: < 5)
Gene RIFs: 54   (req: <= 3)
Antibodies: 1392   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 837.16   (req: >= 5)
Gene RIFs: 54   (req: > 3)
Antibodies: 1392   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0