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Tbio
B3GAT1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

Protein Summary
Description
Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group. The protein encoded by this gene is a member of the glucuronyltransferase gene family. These enzymes exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product functions as the key enzyme in a glucuronyl transfer reaction during the biosynthesis of the carbohydrate epitope HNK-1 (human natural killer-1, also known as CD57 and LEU7). Alternate transcriptional splice variant ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312527
  • ENSP00000307875
  • ENSG00000109956
  • ENST00000392580
  • ENSP00000376359
  • ENST00000524765
  • ENSP00000433847

Symbol
  • GLCATP
  • NK1
  • CD57
  • HNK1
  • LEU7
  • NK-1
  • GLCATP
  • GLCUATP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.69
virus perturbation
0.68
cellular component
0.67
biological term
0.62
pathway
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 760.44   (req: < 5)
Gene RIFs: 48   (req: <= 3)
Antibodies: 1392   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 760.44   (req: >= 5)
Gene RIFs: 48   (req: > 3)
Antibodies: 1392   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
insomnia measurement
1
1
0
1.1
44.7
N-glycan measurement
1
1
1
36.4
prostate carcinoma
1
1
0
1.1
13.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
insomnia measurement
0
1.1
44.7
N-glycan measurement
1
36.4
prostate carcinoma
0
1.1
13.5
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
beta-1,3-glucuronyltransferase 1
VGNC:48891
466859
Macaque
beta-1,3-glucuronyltransferase 1
695293
Mouse
MGI:1924148
76898
Rat
RGD:70880
117108
Dog
beta-1,3-glucuronyltransferase 1
VGNC:38337
489265
Species
Name
OMA
EggNOG
Inparanoid
Chimp
beta-1,3-glucuronyltransferase 1
Macaque
beta-1,3-glucuronyltransferase 1
Mouse
Rat
Dog
beta-1,3-glucuronyltransferase 1
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9P2W7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (9)
A tetrasaccharide linker sequence is required for GAG synthesis (R-HSA-1971475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
A tetrasaccharide linker sequence is required for GAG synthesis
Reactome
Chondroitin sulfate/dermatan sulfate metabolism
Reactome
Glycosaminoglycan metabolism
Reactome
Heparan sulfate/heparin (HS-GAG) metabolism
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
A tetrasaccharide linker sequence is required for GAG synthesis
Chondroitin sulfate/dermatan sulfate metabolism
Glycosaminoglycan metabolism
Heparan sulfate/heparin (HS-GAG) metabolism
Metabolism
Protein-Protein Interactions (170)
1 – 10 of 170
CHST10
Tbio
Family: Enzyme
Novelty: 0.06829376
Score: 0.968
Data Source: STRINGDB
GPC2
Tbio
Novelty: 0.02182363
Score: 0.934
Data Source: STRINGDB
B4GALT2
Tbio
Family: Enzyme
Novelty: 0.03492512
Score: 0.934
Data Source: STRINGDB
SDC1
Tbio
Novelty: 0.00044792
Score: 0.932
Data Source: STRINGDB
NCAN
Tbio
Novelty: 0.00401824
Score: 0.929
Data Source: STRINGDB
B4GALT3
Tbio
Family: Enzyme
Novelty: 0.04015046
Score: 0.922
Data Source: STRINGDB
SDC3
Tbio
Novelty: 0.01095269
Score: 0.918
Data Source: STRINGDB
GPC3
Tbio
Novelty: 0.00151823
Score: 0.917
Data Source: STRINGDB
GPC5
Tbio
Novelty: 0.01257358
Score: 0.915
Data Source: STRINGDB
SDC2
Tbio
Novelty: 0.00597758
Score: 0.915
Data Source: STRINGDB
Publication Statistics
PubMed Score  760.44

PubMed score by year
PubTator Score  1350.86

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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