Tbio GNG13 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13

Protein Summary

Description

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Heterotrimeric G proteins, which consist of alpha (see MIM 139320), beta (see MIM 139380), and gamma subunits, function as signal transducers for the 7-transmembrane-helix G protein-coupled receptors. GNG13 is a gamma subunit that is expressed in taste, retinal, and neuronal tissues and plays a key role in taste transduction (Li et al., 2006 [PubMed 16473877]).[supplied by OMIM, Oct 2009]

Uniprot Accession IDs

• Q9P2W3
• B2R5C8
• Q52LX0
• Q9UJJ3

Gene Name

• GNG13

Ensembl ID

• ENST00000248150
• ENSP00000248150
• ENSG00000127588

Symbol

• h2-35
• G(gamma)13

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	0.68
kinase perturbation	0.66
PubMedID	0.59
cell type or tissue	0.56
transcription factor	0.48

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.04   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 49   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.04   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0