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Tbio
PSMC3IP
Homologous-pairing protein 2 homolog

Protein Summary
Description
Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3. Acts as a tissue specific coactivator of hormone-dependent transcription mediated by nuclear receptors. This gene encodes a protein that functions in meiotic recombination. It is a subunit of the PSMC3IP/MND1 complex, which interacts with PSMC3/TBP1 to stimulate DMC1- and RAD51-mediated strand exchange during meiosis. The protein encoded by this gene can al ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253789
  • ENSP00000253789
  • ENSG00000131470
  • ENST00000393795
  • ENSP00000377384
  • ENST00000590760
  • ENSP00000466381

Symbol
  • HOP2
  • TBPIP
  • HOP2
  • ODG3
  • GT198
  • TBPIP
  • HUMGT198A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
kinase perturbation
0.91
virus perturbation
0.88
transcription factor perturbation
0.8
transcription factor binding site profile
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.79   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 66   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.79   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
4
2
1
91.4
waist-hip ratio
3
6
6
82
BMI-adjusted waist-hip ratio
1
4
4
76.4
sex hormone-binding globulin measurement
4
2
4
75.4
triglyceride measurement
3
2
3
68.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
91.4
waist-hip ratio
6
82
BMI-adjusted waist-hip ratio
4
76.4
sex hormone-binding globulin measurement
4
75.4
triglyceride measurement
3
68.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PSMC3 interacting protein
VGNC:9541
742143
Macaque
PSMC3 interacting protein
710658
Mouse
MGI:1098610
19183
Rat
RGD:621885
140938
Dog
PSMC3 interacting protein
VGNC:45103
607659
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PSMC3 interacting protein
Macaque
PSMC3 interacting protein
Mouse
Rat
Dog
PSMC3 interacting protein
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9P2W1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (53)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Meiosis
Reactome
Meiotic recombination
Reactome
Reproduction
Name
Explore in Pharos
Explore in Source
Cell Cycle
Meiosis
Meiotic recombination
Reproduction
Gene Ontology Terms (4)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (67)
1 – 10 of 67
MND1
Tbio
Novelty:  0.02206181
p_int:  0.999999999
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
EIF1AD
Tdark
Novelty:  0.23915521
p_int:  0.99984941
p_ni:  4.13e-7
p_wrong:  0.000150177
Data Source:  BioPlex
RAD51
Tchem
Novelty:  0.00011516
Score:  0.974
Data Source:  STRINGDB
DMC1
Tbio
Novelty:  0.05445277
Score:  0.97
Data Source:  STRINGDB
BRCA1
Tchem
Novelty:  0.00011146
Score:  0.949
Data Source:  STRINGDB
BRCA2
Tbio
Novelty:  0.0002217
Score:  0.925
Data Source:  STRINGDB
RPA3
Tbio
Novelty:  0.00887858
Score:  0.923
Data Source:  STRINGDB
RPA1
Tchem
Novelty:  0.00212665
Score:  0.914
Data Source:  STRINGDB
H2AFX
Tbio
Novelty:  0.00048694
Score:  0.908
Data Source:  STRINGDB
CDK4
Tclin
Family:  Kinase
Novelty:  0.00036742
Score:  0.904
Data Source:  STRINGDB
Publication Statistics
PubMed Score  21.79

PubMed score by year
PubTator Score  17.3

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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