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Tbio
SLC17A7
Vesicular glutamate transporter 1

Protein Summary
Description
Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi cotransporter family. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221485
  • ENSP00000221485
  • ENSG00000104888
  • ENST00000600601
  • ENSP00000470338

Symbol
  • BNPI
  • VGLUT1
  • BNPI
  • VGLUT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
cellular component
0.75
gene perturbation
0.66
small molecule perturbation
0.61
biological process
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 606.93   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 220   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 606.93   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (14)
Glutamate Neurotransmitter Release Cycle (R-HSA-210500)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glutamate Neurotransmitter Release Cycle
Reactome
Neuronal System
Reactome
Neurotransmitter release cycle
Reactome
Organic anion transporters
Reactome
SLC-mediated transmembrane transport
Name
Explore in Pharos
Explore in Source
Glutamate Neurotransmitter Release Cycle
Neuronal System
Neurotransmitter release cycle
Organic anion transporters
SLC-mediated transmembrane transport
Gene Ontology Terms (27)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (225)
1 – 10 of 225
SLC32A1
Tchem
Family: Transporter
Novelty: 0.00237273
Score: 0.988
Data Source: STRINGDB
SYT1
Tbio
Novelty: 0.00176103
Score: 0.976
Data Source: Reactome,STRINGDB
SNAP25
Tclin
Novelty: 0.00148905
Score: 0.972
Data Source: STRINGDB
VAMP2
Tbio
Novelty: 0.00187736
Score: 0.967
Data Source: Reactome,STRINGDB
SLC18A3
Tchem
Family: Transporter
Novelty: 0.00169007
Score: 0.958
Data Source: STRINGDB
RAB3A
Tbio
Family: Enzyme
Novelty: 0.0043532
Score: 0.957
Data Source: Reactome,STRINGDB
RIMS1
Tbio
Novelty: 0.01126545
Score: 0.954
Data Source: STRINGDB
CPLX1
Tbio
Novelty: 0.01434543
Score: 0.952
Data Source: STRINGDB
STX1A
Tbio
Novelty: 0.00087207
Score: 0.943
Data Source: STRINGDB
UNC13B
Tbio
Novelty: 0.00429808
Score: 0.943
Data Source: STRINGDB
Publication Statistics
PubMed Score  606.93

PubMed score by year
PubTator Score  131.77

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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