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Tbio
SLC17A7
Vesicular glutamate transporter 1

Protein Summary
Description
Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi cotransporter family. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221485
  • ENSP00000221485
  • ENSG00000104888
  • ENST00000600601
  • ENSP00000470338

Symbol
  • BNPI
  • VGLUT1
  • BNPI
  • VGLUT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
cellular component
0.75
gene perturbation
0.66
small molecule perturbation
0.61
biological process
0.6


Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 617.82   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 220   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 617.82   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (31)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
2
9
10
99.3
serum albumin measurement
4
8
10
99.3
calcium measurement
1
4
4
95.1
sex hormone-binding globulin measurement
6
2
6
92.5
serum non-albumin protein measurement
2
4
5
88
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
10
99.3
serum albumin measurement
10
99.3
calcium measurement
4
95.1
sex hormone-binding globulin measurement
6
92.5
serum non-albumin protein measurement
5
88
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
solute carrier family 17 member 7
574349
Mouse
MGI:1920211
72961
Rat
RGD:620101
116638
Dog
solute carrier family 17 member 7
VGNC:46252
476415
Cow
solute carrier family 17 member 7
VGNC:34702
518849
Species
Name
OMA
EggNOG
Inparanoid
Macaque
solute carrier family 17 member 7
Mouse
Rat
Dog
solute carrier family 17 member 7
Cow
solute carrier family 17 member 7
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9P2U7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (14)
Glutamate Neurotransmitter Release Cycle (R-HSA-210500)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glutamate Neurotransmitter Release Cycle
Reactome
Neuronal System
Reactome
Neurotransmitter release cycle
Reactome
Organic anion transporters
Reactome
SLC-mediated transmembrane transport
Name
Explore in Pharos
Explore in Source
Glutamate Neurotransmitter Release Cycle
Neuronal System
Neurotransmitter release cycle
Organic anion transporters
SLC-mediated transmembrane transport
Gene Ontology Terms (27)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (225)
1 – 10 of 225
SLC32A1
Tchem
Family:  Transporter
Novelty:  0.00237273
Score:  0.988
Data Source:  STRINGDB
SYT1
Tbio
Novelty:  0.00176103
Score:  0.976
Data Source:  Reactome,STRINGDB
SNAP25
Tclin
Novelty:  0.00148905
Score:  0.972
Data Source:  STRINGDB
VAMP2
Tbio
Novelty:  0.00187736
Score:  0.967
Data Source:  Reactome,STRINGDB
SLC18A3
Tchem
Family:  Transporter
Novelty:  0.00169007
Score:  0.958
Data Source:  STRINGDB
RAB3A
Tbio
Family:  Enzyme
Novelty:  0.0043532
Score:  0.957
Data Source:  Reactome,STRINGDB
RIMS1
Tbio
Novelty:  0.01126545
Score:  0.954
Data Source:  STRINGDB
CPLX1
Tbio
Novelty:  0.01434543
Score:  0.952
Data Source:  STRINGDB
STX1A
Tbio
Novelty:  0.00087207
Score:  0.943
Data Source:  STRINGDB
UNC13B
Tbio
Novelty:  0.00429808
Score:  0.943
Data Source:  STRINGDB
Publication Statistics
PubMed Score  617.82

PubMed score by year
PubTator Score  131.77

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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