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Tbio
GMPR2
GMP reductase 2

Protein Summary
Description
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (PubMed:12009299, PubMed:12669231, PubMed:16359702, PubMed:22037469). Plays a role in modulating cellular differentiation (PubMed:12669231). This gene encodes an enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of guanosine monophosphate (GMP) to inosine monophosphate (IMP). The protein also functions in the re-utilization of free intracellular bases and purine nucleosides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355299
  • ENSP00000347449
  • ENSG00000100938
  • ENST00000399440
  • ENSP00000382369
  • ENST00000420554
  • ENSP00000392859
  • ENST00000456667
  • ENSP00000405743
  • ENST00000559836
  • ENSP00000453299
  • ENST00000642276
  • ENSP00000496504
  • ENSG00000284752
  • ENST00000643803
  • ENSP00000495708
  • ENST00000644066
  • ENSP00000494224
  • ENST00000645781
  • ENSP00000496234
  • ENST00000647320
  • ENSP00000495583

Symbol
  • GMPR 2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.82
kinase perturbation
0.81
transcription factor
0.67
transcription factor binding site profile
0.67
tissue sample
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.64   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 108   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.64   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (94)
SNX17
Tbio
Novelty:  0.03960737
p_int:  0.97768339
p_ni:  0.022316582
p_wrong:  2.7e-8
Score:  0.529
Data Source:  BioPlex,STRINGDB
GMPR
Tbio
Family:  Enzyme
Novelty:  0.03505649
p_int:  0.972635799
p_ni:  0.027364201
Score:  0.937
Data Source:  BioPlex,STRINGDB
GMPS
Tbio
Family:  Enzyme
Novelty:  0.00611806
Score:  0.986
Data Source:  STRINGDB
ADSSL1
Tbio
Family:  Enzyme
Novelty:  0.0511949
Score:  0.962
Data Source:  STRINGDB
ADSS
Tchem
Family:  Enzyme
Novelty:  0.0126472
Score:  0.959
Data Source:  STRINGDB
ITPA
Tbio
Family:  Enzyme
Novelty:  0.00235169
Score:  0.951
Data Source:  STRINGDB
APRT
Tchem
Family:  Enzyme
Novelty:  0.00483077
Score:  0.946
Data Source:  STRINGDB
AMPD2
Tchem
Family:  Enzyme
Novelty:  0.01510718
Score:  0.942
Data Source:  STRINGDB
ATIC
Tchem
Novelty:  0.00466845
Score:  0.94
Data Source:  STRINGDB
AMPD3
Tchem
Family:  Enzyme
Novelty:  0.01230806
Score:  0.94
Data Source:  STRINGDB
Nearest Tclin Targets (46)
Explore Nearest Tclin Targets
1 – 5 of 30
PDE6D
Tclin
Family:  Enzyme
KEGG Distance:  3
Common Pathways:  2
PDE5A
Tclin
Family:  Enzyme
KEGG Distance:  3
Common Pathways:  2
PDE8A
Tclin
Family:  Enzyme
KEGG Distance:  3
Common Pathways:  2
PDE2A
Tclin
Family:  Enzyme
KEGG Distance:  3
Common Pathways:  2
GUCY2C
Tclin
Family:  Kinase
KEGG Distance:  3
Common Pathways:  2
Pathways (7)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleotide salvage
Reactome
Purine salvage
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleotide salvage
Purine salvage
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
telomere length
1
1
1
82.9
telomere length
1
1
1
82.9
platelet count
2
2
2
75
platelet count
2
2
2
75
mean corpuscular volume
2
2
2
62
Items per page:
1 – 5 of 16
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
telomere length
1
82.9
telomere length
1
82.9
platelet count
2
75
platelet count
2
75
mean corpuscular volume
2
62
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
guanosine monophosphate reductase 2
VGNC:12647
745051
Macaque
guanosine monophosphate reductase 2
715719
Mouse
MGI:1917903
105446
Opossum
guanosine monophosphate reductase 2
100030802
Anole lizard
guanosine monophosphate reductase 2
100555688
Species
Name
OMA
EggNOG
Inparanoid
Chimp
guanosine monophosphate reductase 2
Macaque
guanosine monophosphate reductase 2
Mouse
Opossum
guanosine monophosphate reductase 2
Anole lizard
guanosine monophosphate reductase 2
Publication Statistics
PubMed Score 5.64
PubMed score by year
PubTator Score 3.77
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title