Protein Summary
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (PubMed:12009299, PubMed:12669231, PubMed:16359702, PubMed:22037469). Plays a role in modulating cellular differentiation (PubMed:12669231). This gene encodes an enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of guanosine monophosphate (GMP) to inosine monophosphate (IMP). The protein also functions in the re-utilization of free intracellular bases and purine nucleosides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]
- ENST00000355299
- ENSP00000347449
- ENSG00000100938
- ENST00000399440
- ENSP00000382369
- ENST00000420554
- ENSP00000392859
- ENST00000456667
- ENSP00000405743
- ENST00000559836
- ENSP00000453299
- ENST00000642276
- ENSP00000496504
- ENSG00000284752
- ENST00000643803
- ENSP00000495708
- ENST00000644066
- ENSP00000494224
- ENST00000645781
- ENSP00000496234
- ENST00000647320
- ENSP00000495583
- GMPR 2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
histone modification site profile | 0.82 | ||
kinase perturbation | 0.81 | ||
transcription factor | 0.67 | ||
transcription factor binding site profile | 0.67 | ||
tissue sample | 0.65 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6.5 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 108 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6.5 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 108 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0