Tchem SUCLA2 Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

Protein Summary

Description

ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA (PubMed:15877282). The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit (By similarity). Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. The protein encoded by this gene is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. SCS-A hydrolyzes ATP to convert succinate to succinyl-CoA. Defects in this gene are a cause of myopathic mitochondrial DNA depletion syndrome. A pseudogene of this gene has been found on chromosome 6. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9P2R7
• B2RDE7
• O95194
• Q5T9Q4
• Q5T9Q6
• Q9NV21
• Q9NVP7

Gene Name

• SUCLA2

Ensembl ID

• ENST00000378654
• ENSP00000367923
• ENSG00000136143
• ENST00000643584
• ENSP00000494987
• ENST00000646932
• ENSP00000494360

Symbol

• A-SCS
• A-BETA
• MTDPS5
• SCS-betaA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
molecular function	0.94
disease perturbation	0.9
histone modification site profile	0.85
virus perturbation	0.85

Protein Classes

PANTHER Classes

Protein / Ligase / Succinate--coa Ligase [Adp-forming] Subunit Beta, Mitochondrial

DTO Classes

Protein / Enzyme / Ligase / Succinate--coa Ligase [Adp-forming] Subunit Beta, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.72   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 106   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.72   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0