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Tbio
SUCLA2
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

Protein Classes
Protein Summary
Description
ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA (PubMed:15877282). The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit (By similarity). Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. The protein encoded by this gene is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. SCS-A hydrolyzes ATP to convert succinate to succinyl-CoA. Defects in this gene are a cause of myopathic mitochondrial DNA depletion syndrome. A pseudogene of this gene has been found on chromosome 6. [ ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378654
  • ENSP00000367923
  • ENSG00000136143
  • ENST00000643584
  • ENSP00000494987
  • ENST00000646932
  • ENSP00000494360

Symbol
  • A-SCS
  • A-BETA
  • MTDPS5
  • SCS-betaA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
molecular function
0.94
disease perturbation
0.9
histone modification site profile
0.85
virus perturbation
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.76   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 106   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.76   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hip bone size
1
1
1
46
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hip bone size
1
46
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
succinate-CoA ligase ADP-forming beta subunit
VGNC:9815
452711
Macaque
succinate-CoA ligase ADP-forming beta subunit
704434
Mouse
MGI:1306775
20916
Rat
RGD:1309397
361071
Dog
succinate-CoA ligase ADP-forming beta subunit
485448
Species
Name
OMA
EggNOG
Inparanoid
Chimp
succinate-CoA ligase ADP-forming beta subunit
Macaque
succinate-CoA ligase ADP-forming beta subunit
Mouse
Rat
Dog
succinate-CoA ligase ADP-forming beta subunit
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9P2R7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
Citric acid cycle (TCA cycle) (R-HSA-71403)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Citric acid cycle (TCA cycle)
Reactome
Metabolism
Reactome
Pyruvate metabolism and Citric Acid (TCA) cycle
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Citric acid cycle (TCA cycle)
Metabolism
Pyruvate metabolism and Citric Acid (TCA) cycle
The citric acid (TCA) cycle and respiratory electron transport
Gene Ontology Terms (11)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Protein-Protein Interactions (148)
1 – 10 of 148
SUCLG1
Tbio
Family: Enzyme
Novelty: 0.01113643
p_int: 0.999999561
p_ni: 4.39e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
METAP2
Tchem
Family: Enzyme
Novelty: 0.00570955
p_int: 0.999834674
p_ni: 0.000165326
Score: 0.19
Data Source: BioPlex,STRINGDB
RAD21
Tbio
Novelty: 0.00270936
p_int: 0.996691281
p_ni: 0.003308679
p_wrong: 4e-8
Data Source: BioPlex
DNLZ
Tdark
Novelty: 0.10113346
p_int: 0.991606287
p_ni: 0.008393336
p_wrong: 3.76e-7
Data Source: BioPlex
MTIF2
Tbio
Novelty: 0.06681774
p_int: 0.98830874
p_ni: 0.01169126
Score: 0.214
Data Source: BioPlex,STRINGDB
C17orf80
Tbio
Novelty: 0.15267004
p_int: 0.985856379
p_ni: 0.014143621
Data Source: BioPlex
ZMYND19
Tdark
Novelty: 0.3590069
p_int: 0.983775051
p_ni: 0.016221918
p_wrong: 0.000003031
Data Source: BioPlex
IQGAP2
Tbio
Family: Enzyme
Novelty: 0.03317992
p_int: 0.938286298
p_ni: 0.061713702
Score: 0.242
Data Source: BioPlex,STRINGDB
GTPBP10
Tbio
Novelty: 0.18563864
p_int: 0.929224791
p_ni: 0.070711172
p_wrong: 0.000064037
Score: 0.219
Data Source: BioPlex,STRINGDB
MKLN1
Tbio
Novelty: 0.05014385
p_int: 0.922681664
p_ni: 0.077318336
Data Source: BioPlex
Publication Statistics
PubMed Score  45.76

PubMed score by year
PubTator Score  54.16

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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