Tbio RERE Arginine-glutamic acid dipeptide repeats protein

Protein Summary

Description

Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death. This gene encodes a member of the atrophin family of arginine-glutamic acid (RE) dipeptide repeat-containing proteins. The encoded protein co-localizes with a transcription factor in the nucleus, and its overexpression triggers apoptosis. A similar protein in mouse associates with histone deacetylase and is thought to function as a transcriptional co-repressor during embryonic development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9P2R6
• O43393
• O75046
• O75359
• Q5VXL9
• Q6P6B9
• Q9Y2W4

Gene Name

• RERE

Ensembl ID

• ENST00000337907
• ENSP00000338629
• ENSG00000142599
• ENST00000400908
• ENSP00000383700
• ENST00000476556
• ENSP00000422246

Symbol

• ARG
• ARP
• ATN1L
• KIAA0458
• ARG
• ARP
• DNB1
• ATN1L
• NEDBEH

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
virus perturbation	0.96
transcription factor	0.94
protein domain	0.92
kinase perturbation	0.91

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.84   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 147   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.84   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0