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Tdark
KLHL13
Kelch-like protein 13

Protein Summary
Description
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis. This gene encodes a BTB and kelch domain containing protein and belongs to the kelch repeat domain containing superfamily of proteins. The encoded protein functions as an adaptor protein that complexes with Cullin 3 and other proteins to form the Cullin 3-based E3 ubiquitin-protein ligase complex. This complex is necessary for proper chromosome segregation and completion of cytokinesis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262820
  • ENSP00000262820
  • ENSG00000003096
  • ENST00000469946
  • ENSP00000419803
  • ENST00000540167
  • ENSP00000441029
  • ENST00000541812
  • ENSP00000444450
  • ENST00000545703
  • ENSP00000440707

Symbol
  • BKLHD2
  • KIAA1309
  • BKLHD2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
transcription factor perturbation
0.8
virus perturbation
0.79
trait
0.75
cell type or tissue
0.63


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.25   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 126   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.25   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 126   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
kelch like family member 13
710546
Mouse
MGI:1914705
67455
Rat
RGD:1559646
313445
Dog
kelch like family member 13
VGNC:42449
492088
Horse
kelch like family member 13
VGNC:19462
100053772
Species
Name
OMA
EggNOG
Inparanoid
Macaque
kelch like family member 13
Mouse
Rat
Dog
kelch like family member 13
Horse
kelch like family member 13
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9P2N7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Gene Ontology Terms (8)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (321)
1 – 10 of 321
KLHL28
Tdark
Novelty: 1.1777024
p_int: 0.980013763
p_ni: 0.019986237
Score: 0.199
Data Source: BioPlex,STRINGDB
KLHL9
Tdark
Novelty: 0.22434722
p_int: 0.955507154
p_ni: 0.044492846
Score: 0.953
Data Source: BioPlex,STRINGDB
KLHL22
Tbio
Novelty: 0.24456252
p_int: 0.915413431
p_ni: 0.084586569
Score: 0.955
Data Source: BioPlex,STRINGDB
PPP1R16B
Tbio
Family: Enzyme
Novelty: 0.08773047
p_int: 0.827611618
p_ni: 0.172388382
Score: 0.345
Data Source: BioPlex,STRINGDB
CUL3
Tbio
Novelty: 0.0028737
Score: 0.995
Data Source: STRINGDB
AURKB
Tchem
Family: Kinase
Novelty: 0.00100972
Score: 0.988
Data Source: STRINGDB
COPS4
Tbio
Novelty: 0.04672417
Score: 0.955
Data Source: STRINGDB
COPS2
Tbio
Novelty: 0.03509351
Score: 0.954
Data Source: STRINGDB
UBE2D1
Tbio
Novelty: 0.00865867
Score: 0.947
Data Source: STRINGDB
KLHL21
Tbio
Novelty: 0.20694121
Score: 0.946
Data Source: STRINGDB
Publication Statistics
PubMed Score  3.25

PubMed score by year
PubTator Score  0.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer