Tbio KANSL3 KAT8 regulatory NSL complex subunit 3

Protein Summary

Description

As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.

Uniprot Accession IDs

• Q9P2N6
• A1L184
• D3DXH3
• D3DXH4
• Q05BU4
• Q6P3X2
• Q6PJH6
• Q86T19
• Q96L64
• Q9H0C9
• Q9H8C9
• Q9HAP8
• Q9NWE5

Gene Name

• KANSL3

Ensembl ID

• ENST00000420155
• ENSP00000414426
• ENSG00000114982
• ENST00000431828
• ENSP00000396749

Symbol

• KIAA1310
• NSL3
• PRTD
• SI1
• NSL3
• Rcd1
• KIAA1310

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.82
cellular component	0.81
transcription factor	0.76
cell type or tissue	0.69
gene perturbation	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1320.75   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 106   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1320.75   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0