Tbio CGN Cingulin

Protein Summary

Description

Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.

Uniprot Accession IDs

• Q9P2M7
• A6H8L3
• A7MD22
• Q5T386
• Q9NR25

Gene Name

• CGN

Ensembl ID

• ENST00000271636
• ENSP00000271636
• ENSG00000143375

Symbol

• KIAA1319

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.84
histone modification site profile	0.75
drug perturbation	0.71
interacting protein	0.67
cellular component	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.43   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 86   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.43   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0