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Tbio
TBC1D14
TBC1 domain family member 14

Protein Summary
Description
Negative regulator of starvation-induced autophagosome formation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000409757
  • ENSP00000386921
  • ENSG00000132405
  • ENST00000448507
  • ENSP00000404041
  • ENST00000451522
  • ENSP00000388886

Symbol
  • KIAA1322
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.92
virus perturbation
0.85
transcription factor
0.81
disease perturbation
0.79
kinase perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.2   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.2   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
2
3
85
myeloid white cell count
1
1
1
77.7
mean platelet volume
2
2
2
57.8
monocyte percentage of leukocytes
2
2
2
56.6
monocyte count
1
1
1
48.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
85
myeloid white cell count
1
77.7
mean platelet volume
2
57.8
monocyte percentage of leukocytes
2
56.6
monocyte count
1
48.3
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (4)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
Rab regulation of trafficking
Reactome
TBC/RABGAPs
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
Rab regulation of trafficking
TBC/RABGAPs
Vesicle-mediated transport
Gene Ontology Terms (14)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (54)
1 – 10 of 54
TRAPPC11
Tbio
Novelty: 0.05737444
p_int: 0.999973357
p_ni: 0.000026643
Score: 0.869
Data Source: BioPlex,STRINGDB
TRAPPC12
Tbio
Novelty: 0.09847363
p_int: 0.999909303
p_ni: 0.000090696
Score: 0.907
Data Source: BioPlex,STRINGDB
TRAPPC13
Tdark
Novelty: 0.4415
p_int: 0.999830797
p_ni: 0.000167693
p_wrong: 0.00000151
Score: 0.891
Data Source: BioPlex,STRINGDB
GRK2
Tchem
Family: Kinase
Novelty: 0.00200696
p_int: 0.999595419
p_ni: 0.000404581
Score: 0.239
Data Source: BioPlex,STRINGDB
TRAPPC8
Tdark
Novelty: 0.07711264
p_int: 0.999456458
p_ni: 0.000543528
p_wrong: 1.4e-8
Score: 0.947
Data Source: BioPlex,STRINGDB
TRAPPC4
Tbio
Novelty: 0.05749912
p_int: 0.998615816
p_ni: 0.001384184
Score: 0.857
Data Source: BioPlex,STRINGDB
TRAPPC3
Tbio
Novelty: 0.0360262
p_int: 0.993655677
p_ni: 0.006344323
Score: 0.824
Data Source: BioPlex,STRINGDB
TRAPPC6B
Tbio
Novelty: 0.15086531
p_int: 0.978749012
p_ni: 0.021250777
p_wrong: 2.11e-7
Score: 0.814
Data Source: BioPlex,STRINGDB
SELENBP1
Tbio
Novelty: 0.00758018
p_int: 0.977254789
p_ni: 0.022737823
p_wrong: 0.000007388
Data Source: BioPlex
HEPHL1
Tbio
Novelty: 0.44678065
p_int: 0.977193824
p_ni: 0.022778497
p_wrong: 0.000027679
Data Source: BioPlex
Publication Statistics
PubMed Score  4.20

PubMed score by year
PubTator Score  3.93

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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