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Tbio
TBC1D14
TBC1 domain family member 14

Protein Summary
Description
Negative regulator of starvation-induced autophagosome formation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000409757
  • ENSP00000386921
  • ENSG00000132405
  • ENST00000448507
  • ENSP00000404041
  • ENST00000451522
  • ENSP00000388886

Symbol
  • KIAA1322
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.92
virus perturbation
0.85
transcription factor
0.81
disease perturbation
0.79
kinase perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.63   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.63   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
TRAPPC11
Tbio
Novelty:  0.05737444
p_int:  0.999973357
p_ni:  0.000026643
Score:  0.869
Data Source:  BioPlex,STRINGDB
TRAPPC12
Tbio
Novelty:  0.09847363
p_int:  0.999909303
p_ni:  0.000090696
Score:  0.907
Data Source:  BioPlex,STRINGDB
TRAPPC13
Tdark
Novelty:  0.4415
p_int:  0.999830797
p_ni:  0.000167693
p_wrong:  0.00000151
Score:  0.891
Data Source:  BioPlex,STRINGDB
GRK2
Tchem
Family:  Kinase
Novelty:  0.00200696
p_int:  0.999595419
p_ni:  0.000404581
Score:  0.239
Data Source:  BioPlex,STRINGDB
TRAPPC8
Tdark
Novelty:  0.07711264
p_int:  0.999456458
p_ni:  0.000543528
p_wrong:  1.4e-8
Score:  0.947
Data Source:  BioPlex,STRINGDB
TRAPPC4
Tbio
Novelty:  0.05749912
p_int:  0.998615816
p_ni:  0.001384184
Score:  0.857
Data Source:  BioPlex,STRINGDB
TRAPPC3
Tbio
Novelty:  0.0360262
p_int:  0.993655677
p_ni:  0.006344323
Score:  0.824
Data Source:  BioPlex,STRINGDB
TRAPPC6B
Tbio
Novelty:  0.15086531
p_int:  0.978749012
p_ni:  0.021250777
p_wrong:  2.11e-7
Score:  0.814
Data Source:  BioPlex,STRINGDB
SELENBP1
Tbio
Novelty:  0.00758018
p_int:  0.977254789
p_ni:  0.022737823
p_wrong:  0.000007388
Data Source:  BioPlex
HEPHL1
Tbio
Novelty:  0.44678065
p_int:  0.977193824
p_ni:  0.022778497
p_wrong:  0.000027679
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
Rab regulation of trafficking
Reactome
TBC/RABGAPs
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
Rab regulation of trafficking
TBC/RABGAPs
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
7
7
8
5.7
99.3
mean platelet volume
4
6
7
98.9
monocyte count
6
4
7
94.8
monocyte percentage of leukocytes
2
5
5
85.3
neutrophil count
3
3
4
83
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
8
5.7
99.3
mean platelet volume
7
98.9
monocyte count
7
94.8
monocyte percentage of leukocytes
5
85.3
neutrophil count
4
83
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TBC1 domain family member 14
VGNC:2962
471132
Macaque
TBC1 domain family member 14
722719
Mouse
MGI:1098708
100855
Rat
RGD:1309993
360956
Dog
TBC1 domain family member 14
VGNC:47133
488781
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TBC1 domain family member 14
Macaque
TBC1 domain family member 14
Mouse
Rat
Dog
TBC1 domain family member 14
Publication Statistics
PubMed Score 4.63
PubMed score by year
PubTator Score 3.93
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title