Tbio WDR35 WD repeat-containing protein 35

Protein Summary

Description

As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport, it is involved in ciliogenesis (PubMed:21473986, PubMed:28400947). May promote CASP3 activation and TNF-stimulated apoptosis. This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Two patients with Sensenbrenner syndrome / cranioectodermal dysplasia (CED) were identified with mutations in this gene, consistent with a possible ciliary function.[provided by RefSeq, Sep 2010]

Uniprot Accession IDs

• Q9P2L0
• B3KVI5
• Q4ZG01
• Q8NE11

Gene Name

• WDR35

Ensembl ID

• ENST00000281405
• ENSP00000281405
• ENSG00000118965
• ENST00000345530
• ENSP00000314444

Symbol

• IFT121
• KIAA1336
• CED2
• IFTA1
• SRTD7
• IFT121

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.89
cell type or tissue	0.64
phenotype	0.64
tissue sample	0.62
cellular component	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.37   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 56   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.37   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 56   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (93)

Explore Interacting Targets

1 – 10 of 93

• See Interactions on String-DB

IFT43

Tbio

Novelty:  0.00478274

p_int:  0.999999989

p_ni:  1.1e-8

Score:  0.998

Data Source:  BioPlex,STRINGDB

TULP3

Tbio

Family:  TF

Novelty:  0.06911636

p_int:  0.999999805

p_ni:  1.29e-7

p_wrong:  6.6e-8

Score:  0.982

Data Source:  BioPlex,Reactome,STRINGDB

C11orf74

Tbio

Novelty:  0.17027595

p_int:  0.99999973

p_ni:  1.56e-7

p_wrong:  1.15e-7

Score:  0.863

Data Source:  BioPlex,STRINGDB

IFT122

Tbio

Novelty:  0.02235986

p_int:  0.999988196

p_ni:  0.000011798

p_wrong:  6e-9

Score:  0.994

Data Source:  BioPlex,Reactome,STRINGDB

TULP2

Tdark

Family:  TF

Novelty:  0.20144336

p_int:  0.969242921

p_ni:  0.01100463

p_wrong:  0.019752449

Score:  0.69

Data Source:  BioPlex,STRINGDB

DNAJC7

Tbio

Novelty:  0.02133191

p_int:  0.920559119

p_ni:  0.036450268

p_wrong:  0.042990613

Score:  0.307

Data Source:  BioPlex,STRINGDB

IFT140

Tbio

Novelty:  0.02872897

Score:  0.994

Data Source:  Reactome,STRINGDB

WDR19

Tbio

Novelty:  0.037197

Score:  0.993

Data Source:  Reactome,STRINGDB

TTC21B

Tbio

Novelty:  0.02480259

Score:  0.991

Data Source:  Reactome,STRINGDB

IFT80

Tbio

Novelty:  0.04862973

Score:  0.988

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (8)

Reactome (6)

WikiPathways (2)

Cilium Assembly (R-HSA-5617833)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cilium Assembly	187 targets	R-HSA-5617833
Reactome	Hedgehog 'off' state	104 targets	R-HSA-5610787
Reactome	Intraflagellar transport	41 targets	R-HSA-5620924
Reactome	Organelle biogenesis and maintenance	276 targets	R-HSA-1852241
Reactome	Signal Transduction	2704 targets	R-HSA-162582

Name	Explore in Pharos	Explore in Source
Cilium Assembly	187 targets	R-HSA-5617833
Hedgehog 'off' state	104 targets	R-HSA-5610787
Intraflagellar transport	41 targets	R-HSA-5620924
Organelle biogenesis and maintenance	276 targets	R-HSA-1852241
Signal Transduction	2704 targets	R-HSA-162582

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (23)

Functions (1)

Components (6)

Processes (16)

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GO Term	Evidence	Assigned by
phosphatidylinositol binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations ()

No disease associations found

GWAS Traits (2)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted waist circumference	EFO_0007789	2	2	2		57.7
waist-hip ratio	EFO_0004343	1	1	1		15.8

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted waist circumference	EFO_0007789	2		57.7
waist-hip ratio	EFO_0004343	1		15.8

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Cell projection
Ciliopathy
Cilium
Cilium biogenesis/degradation
Complete proteome
Cytoplasm
Cytoskeleton
Disease mutation
Ectodermal dysplasia

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted waist circumference
waist-hip ratio

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
cellular phenotype
digestive/alimentary phenotype
embryo phenotype
homeostasis/metabolism phenotype
limbs/digits/tail phenotype
mortality/aging
muscle phenotype
respiratory system phenotype
skeleton phenotype

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	WD repeat domain 35	VGNC:420	459049
Macaque	WD repeat domain 35		716638
Mouse	WD repeat domain 35	MGI:1921932	74682
Rat	WD repeat domain 35	RGD:1564116	503018
Dog	WD repeat domain 35	VGNC:48362	475677

Species	Name	OMA	EggNOG	Inparanoid
Chimp	WD repeat domain 35
Macaque	WD repeat domain 35
Mouse	WD repeat domain 35
Rat	WD repeat domain 35
Dog	WD repeat domain 35

Publication Statistics

PubMed Score 33.37

PubMed score by year

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PubTator Score 19.09

PubTator score by year

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Related Publications

Text Mined References (19)

GeneRif Annotations (11)

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PMID	Year	Title