WDR35
WD repeat-containing protein 35
Protein Summary
As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport, it is involved in ciliogenesis (PubMed:21473986, PubMed:28400947). May promote CASP3 activation and TNF-stimulated apoptosis. This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Two patients with Sensenbrenner syndrome / cranioectodermal dysplasia (CED) were identified with mutations in this gene, consistent with a possible ciliary function.[provided by RefSeq, Sep 2010]
- ENST00000281405
- ENSP00000281405
- ENSG00000118965
- ENST00000345530
- ENSP00000314444
- IFT121
- KIAA1336
- CED2
- IFTA1
- SRTD7
- IFT121
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.89 | ||
cell type or tissue | 0.64 | ||
phenotype | 0.64 | ||
tissue sample | 0.62 | ||
cellular component | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 38.41 (req: < 5)
Gene RIFs: 11 (req: <= 3)
Antibodies: 56 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 38.41 (req: >= 5)
Gene RIFs: 11 (req: > 3)
Antibodies: 56 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (93)
IFT43
Novelty: 0.00478274
p_int: 0.999999989
p_ni: 1.1e-8
Score: 0.998
Data Source: BioPlex,STRINGDB
TULP3
Family: TF
Novelty: 0.06911636
p_int: 0.999999805
p_ni: 1.29e-7
p_wrong: 6.6e-8
Score: 0.982
Data Source: BioPlex,Reactome,STRINGDB
C11orf74
Novelty: 0.17027595
p_int: 0.99999973
p_ni: 1.56e-7
p_wrong: 1.15e-7
Score: 0.863
Data Source: BioPlex,STRINGDB
IFT122
Novelty: 0.02235986
p_int: 0.999988196
p_ni: 0.000011798
p_wrong: 6e-9
Score: 0.994
Data Source: BioPlex,Reactome,STRINGDB
TULP2
Family: TF
Novelty: 0.20144336
p_int: 0.969242921
p_ni: 0.01100463
p_wrong: 0.019752449
Score: 0.69
Data Source: BioPlex,STRINGDB
DNAJC7
Novelty: 0.02133191
p_int: 0.920559119
p_ni: 0.036450268
p_wrong: 0.042990613
Score: 0.307
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (8)
Reactome (6)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cilium Assembly | ||||
Reactome | Hedgehog 'off' state | ||||
Reactome | Intraflagellar transport | ||||
Reactome | Organelle biogenesis and maintenance | ||||
Reactome | Signal Transduction | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cilium Assembly | ||||
Hedgehog 'off' state | ||||
Intraflagellar transport | ||||
Organelle biogenesis and maintenance | ||||
Signal Transduction | ||||
Viral Interactions (0)
Gene Ontology Terms (23)
Functions (1)
Components (6)
Processes (16)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
BMI-adjusted waist circumference | 2 | 2 | 2 | 47.6 | |||||
BMI-adjusted waist-hip ratio | 1 | 1 | 1 | 12.1 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
BMI-adjusted waist circumference | 2 | 47.6 | |||||
BMI-adjusted waist-hip ratio | 1 | 12.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | WD repeat domain 35 | VGNC:420 | 459049 | |||||
Macaque | WD repeat domain 35 | 716638 | ||||||
Mouse | MGI:1921932 | 74682 | ||||||
Rat | RGD:1564116 | 503018 | ||||||
Dog | WD repeat domain 35 | VGNC:48362 | 475677 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | WD repeat domain 35 | |||||
Macaque | WD repeat domain 35 | |||||
Mouse | ||||||
Rat | ||||||
Dog | WD repeat domain 35 | |||||
Publication Statistics
PubMed Score 38.41
PubMed score by year
PubTator Score 19.09
PubTator score by year
Related Publications
Text Mined References (19)
GeneRif Annotations (11)
Items per page:
0 of 0
PMID | Year | Title |
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