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Tbio
WDR35
WD repeat-containing protein 35

Protein Summary
Description
As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport, it is involved in ciliogenesis (PubMed:21473986, PubMed:28400947). May promote CASP3 activation and TNF-stimulated apoptosis. This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Two patients with Sensenbrenner syndrome / cranioectodermal dysplasia (CED) were identified with mutations in this gene, consistent with a possible ciliary function.[provided by RefSeq, Sep 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000281405
  • ENSP00000281405
  • ENSG00000118965
  • ENST00000345530
  • ENSP00000314444

Symbol
  • IFT121
  • KIAA1336
  • CED2
  • IFTA1
  • SRTD7
  • IFT121
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
cell type or tissue
0.64
phenotype
0.64
tissue sample
0.62
cellular component
0.58


Related Tools
GENEVA
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.58   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 56   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.58   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 56   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 35
VGNC:420
459049
Macaque
WD repeat domain 35
716638
Mouse
MGI:1921932
74682
Rat
RGD:1564116
503018
Dog
WD repeat domain 35
VGNC:48362
475677
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 35
Macaque
WD repeat domain 35
Mouse
Rat
Dog
WD repeat domain 35
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9P2L0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Cilium Assembly (R-HSA-5617833)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cilium Assembly
Reactome
Hedgehog 'off' state
Reactome
Intraflagellar transport
Reactome
Organelle biogenesis and maintenance
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Cilium Assembly
Hedgehog 'off' state
Intraflagellar transport
Organelle biogenesis and maintenance
Signal Transduction
Gene Ontology Terms (23)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (93)
1 – 10 of 93
IFT43
Tbio
Novelty: 0.00478274
p_int: 0.999999989
p_ni: 1.1e-8
Score: 0.998
Data Source: BioPlex,STRINGDB
TULP3
Tbio
Family: TF
Novelty: 0.06911636
p_int: 0.999999805
p_ni: 1.29e-7
p_wrong: 6.6e-8
Score: 0.982
Data Source: BioPlex,Reactome,STRINGDB
C11orf74
Tbio
Novelty: 0.17027595
p_int: 0.99999973
p_ni: 1.56e-7
p_wrong: 1.15e-7
Score: 0.863
Data Source: BioPlex,STRINGDB
IFT122
Tbio
Novelty: 0.02235986
p_int: 0.999988196
p_ni: 0.000011798
p_wrong: 6e-9
Score: 0.994
Data Source: BioPlex,Reactome,STRINGDB
TULP2
Tdark
Family: TF
Novelty: 0.20144336
p_int: 0.969242921
p_ni: 0.01100463
p_wrong: 0.019752449
Score: 0.69
Data Source: BioPlex,STRINGDB
DNAJC7
Tbio
Novelty: 0.02133191
p_int: 0.920559119
p_ni: 0.036450268
p_wrong: 0.042990613
Score: 0.307
Data Source: BioPlex,STRINGDB
IFT140
Tbio
Novelty: 0.02872897
Score: 0.994
Data Source: Reactome,STRINGDB
WDR19
Tbio
Novelty: 0.037197
Score: 0.993
Data Source: Reactome,STRINGDB
TTC21B
Tbio
Novelty: 0.02480259
Score: 0.991
Data Source: Reactome,STRINGDB
IFT80
Tbio
Novelty: 0.04862973
Score: 0.988
Data Source: STRINGDB
Publication Statistics
PubMed Score  32.58

PubMed score by year
PubTator Score  19.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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