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Tchem
EIF2AK4
eIF-2-alpha kinase GCN2

Protein Summary
Description
Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' in response to low amino acid availability (PubMed:25329545). Plays a role as an activator of the integrated stress response (ISR) required for adapatation to amino acid starvation. Converts phosphorylated eIF-2-alpha/EIF2S1 either to a competitive inhibitor of the translation initiation factor eIF-2B, leading to a global protein synthesis repression, and thus to a reduced overall utilization of amino acids, or to a translational initiation activation of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Binds uncharged tRNAs (By similarity). Involved in cell cycle arrest by promoting cyclin D1 mRNA translation repression after the unfolded protein response pathway (UPR) activation or cell cycle inhibi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263791
  • ENSP00000263791
  • ENSG00000128829
  • ENST00000559624
  • ENSP00000453148

Symbol
  • GCN2
  • KIAA1338
  • GCN2
  • PVOD2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
hub protein
0.94
molecular function
0.91
histone modification site profile
0.79
interacting protein
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 465.65   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 377   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 465.65   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 377   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 9
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (162)
1 – 10 of 162
PPP1CC
Tchem
Family:  Enzyme
Novelty:  0.00465946
p_int:  0.999999915
p_ni:  8.5e-8
Score:  0.838
Data Source:  BioPlex,STRINGDB
PPP1CA
Tchem
Family:  Enzyme
Novelty:  0.00354658
p_int:  0.999999857
p_ni:  1.43e-7
Score:  0.795
Data Source:  BioPlex,STRINGDB
CROT
Tbio
Family:  Enzyme
Novelty:  0.01860427
p_int:  0.959626683
p_ni:  0.040373317
Score:  0.261
Data Source:  BioPlex,STRINGDB
DEF8
Tdark
Novelty:  0.21146806
p_int:  0.927707915
p_ni:  0.072292085
Score:  0.16
Data Source:  BioPlex,STRINGDB
TKT
Tchem
Family:  Enzyme
Novelty:  0.00333936
p_int:  0.899307806
p_ni:  0.100692194
Score:  0.165
Data Source:  BioPlex,STRINGDB
TGM2
Tchem
Family:  Enzyme
Novelty:  0.0005293
p_int:  0.893112416
p_ni:  0.106867735
p_wrong:  0.000019849
Data Source:  BioPlex
PALM2
Tbio
Novelty:  0.03469098
p_int:  0.864084385
p_ni:  0.135886365
p_wrong:  0.00002925
Score:  0.189
Data Source:  BioPlex,STRINGDB
CAPN2
Tchem
Novelty:  0.00431673
p_int:  0.833423425
p_ni:  0.166554707
p_wrong:  0.000021868
Data Source:  BioPlex
PSMC3
Tbio
Family:  Enzyme
Novelty:  0.04026019
p_int:  0.81052491
p_ni:  0.189475084
p_wrong:  6e-9
Data Source:  BioPlex
MDM4
Tchem
Novelty:  0.00321558
p_int:  0.77998981
p_ni:  0.220010179
p_wrong:  1.1e-8
Score:  0.167
Data Source:  BioPlex,STRINGDB
Pathways (5)
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Protein processing in endoplasmic reticulum
KEGG
Autophagy - animal
KEGG
Hepatitis C
KEGG
Measles
KEGG
Herpes simplex virus 1 infection
Name
Explore in Pharos
Explore in Source
Protein processing in endoplasmic reticulum
Autophagy - animal
Hepatitis C
Measles
Herpes simplex virus 1 infection
Gene Ontology Terms (37)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
3
5
95.8
testosterone measurement
4
2
4
89.9
sex hormone-binding globulin measurement
4
2
4
82
reticulocyte measurement
2
2
2
76.7
serum alanine aminotransferase measurement
2
1
1
8.6
75.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
5
95.8
testosterone measurement
4
89.9
sex hormone-binding globulin measurement
4
82
reticulocyte measurement
2
76.7
serum alanine aminotransferase measurement
1
8.6
75.9
Find similar targets by:
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 2 alpha kinase 4
VGNC:2490
453321
Mouse
MGI:1353427
27103
Rat
RGD:1311439
114859
Dog
eukaryotic translation initiation factor 2 alpha kinase 4
VGNC:40259
478257
Horse
eukaryotic translation initiation factor 2 alpha kinase 4
VGNC:17480
100071494
Species
Name
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 2 alpha kinase 4
Mouse
Rat
Dog
eukaryotic translation initiation factor 2 alpha kinase 4
Horse
eukaryotic translation initiation factor 2 alpha kinase 4
Publication Statistics
PubMed Score 465.65
PubMed score by year
PubTator Score 139.59
PubTator score by year
Patents
Patents by year