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Tdark
KLHL42
Kelch-like protein 42

Protein Summary
Description
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. Involved in microtubule dynamics throughout mitosis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381271
  • ENSP00000370671
  • ENSG00000087448

Symbol
  • KIAA1340
  • KLHDC5
  • Ctb9
  • KLHDC5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.85
kinase perturbation
0.84
histone modification site profile
0.78
protein domain
0.73
transcription factor binding site profile
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.8   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 111   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.8   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (358)
CUL3
Tbio
Novelty:  0.0028737
p_int:  0.999997975
p_ni:  0.000002025
Score:  0.977
Data Source:  BioPlex,STRINGDB
UBE2M
Tchem
Novelty:  0.02353106
p_int:  0.999984949
p_ni:  0.000015051
Score:  0.908
Data Source:  BioPlex,STRINGDB
PCMT1
Tbio
Family:  Enzyme
Novelty:  0.01414946
p_int:  0.999952967
p_ni:  0.000047033
Data Source:  BioPlex
OSTF1
Tbio
Novelty:  0.000588
p_int:  0.999808611
p_ni:  0.000191389
Score:  0.175
Data Source:  BioPlex,STRINGDB
MT1F
Tbio
Novelty:  0.03838808
p_int:  0.999510595
p_ni:  0.000489388
p_wrong:  1.7e-8
Data Source:  BioPlex
DCUN1D2
Tchem
Novelty:  1.02957984
p_int:  0.998384316
p_ni:  0.001615433
p_wrong:  2.51e-7
Score:  0.9
Data Source:  BioPlex,STRINGDB
ANKRD39
Tdark
Novelty:  8.68843298
p_int:  0.997967517
p_ni:  0.002032483
Data Source:  BioPlex
TCEAL9
Tdark
Novelty:  0.3050647
p_int:  0.996383035
p_ni:  0.003615601
p_wrong:  0.000001365
Data Source:  BioPlex
KHDRBS2
Tbio
Novelty:  0.01986638
p_int:  0.980454987
p_ni:  0.019545013
Data Source:  BioPlex
GAS2L1
Tbio
Novelty:  0.17484834
p_int:  0.978329905
p_ni:  0.021670084
p_wrong:  1.1e-8
Score:  0.15
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
12
6
4
1.1
97.3
4
2
0
1.1
29.9
pulse pressure measurement
1
1
1
29.8
electrocardiography
1
1
1
17.8
femoral neck bone mineral density
1
1
1
10.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.1
97.3
0
1.1
29.9
pulse pressure measurement
1
29.8
electrocardiography
1
17.8
femoral neck bone mineral density
1
10.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kelch like family member 42
VGNC:5443
465361
Macaque
kelch like family member 42 [Source:HGNC Symbol;Acc:HGNC:29252]
Mouse
MGI:2444786
232539
Rat
RGD:1560924
500367
Dog
kelch like family member 42
VGNC:42473
477659
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kelch like family member 42
Macaque
kelch like family member 42 [Source:HGNC Symbol;Acc:HGNC:29252]
Mouse
Rat
Dog
kelch like family member 42
Publication Statistics
PubMed Score 3.80
PubMed score by year
PubTator Score 2.72
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title