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Tchem
LARS
Leucine--tRNA ligase, cytoplasmic

Protein Summary
Description
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs. This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. A mutation in this gene was found in affected individuals with infantile liver failure syndrome 1. Alternatively spliced transcript variants of this gene have been observed. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274562
  • ENSP00000274562
  • ENSG00000133706
  • ENST00000394434
  • ENSP00000377954
  • ENST00000510191
  • ENSP00000426005

Symbol
  • KIAA1352
  • LRS
  • LEUS
  • LFIS
  • ILFS1
  • LARS1
  • LEURS
  • PIG44
  • RNTLS
  • HSPC192
  • hr025Cl
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
transcription factor perturbation
0.98
protein domain
0.97
molecular function
0.96
virus perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 286.46   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 286.46   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (10)
1 – 10 of 10
CHEMBL264002
Rendered image for CHEMBL264002
CHEMBL421500
Rendered image for CHEMBL421500
CHEMBL340082
Rendered image for CHEMBL340082
CHEMBL341331
Rendered image for CHEMBL341331
CHEMBL4174152
Rendered image for CHEMBL4174152
CHEMBL4163450
Rendered image for CHEMBL4163450
CHEMBL4172643
Rendered image for CHEMBL4172643
CHEMBL332104
Rendered image for CHEMBL332104
CHEMBL4159778
Rendered image for CHEMBL4159778
Protein-Protein Interactions (199)
1 – 10 of 199
SDCCAG8
Tbio
Novelty:  0.0431837
p_int:  0.999993578
p_ni:  0.000006412
p_wrong:  1e-8
Score:  0.686
Data Source:  BioPlex,STRINGDB
RARS
Tchem
Family:  Enzyme
Novelty:  0.00099479
p_int:  0.999986955
p_ni:  0.000013045
Score:  0.998
Data Source:  BioPlex,STRINGDB
TARSL2
Tbio
Family:  Enzyme
Novelty:  0.02406282
p_int:  0.99992882
p_ni:  0.00007118
Score:  0.982
Data Source:  BioPlex,STRINGDB
KARS
Tchem
Family:  Enzyme
Novelty:  0.00386511
p_int:  0.998340387
p_ni:  0.001659613
Score:  0.998
Data Source:  BioPlex,STRINGDB
AIMP1
Tbio
Family:  Enzyme
Novelty:  0.00743447
p_int:  0.99715385
p_ni:  0.00284615
Score:  0.998
Data Source:  BioPlex,STRINGDB
EEF1E1
Tbio
Novelty:  0.06216577
p_int:  0.992659961
p_ni:  0.007340039
Score:  0.993
Data Source:  BioPlex,STRINGDB
DARS
Tbio
Family:  Enzyme
Novelty:  0.01101888
p_int:  0.990205531
p_ni:  0.009794469
Score:  0.998
Data Source:  BioPlex,STRINGDB
EPRS
Tchem
Family:  Enzyme
Novelty:  0.00084896
p_int:  0.989037048
p_ni:  0.010962952
Score:  0.999
Data Source:  BioPlex,STRINGDB
IARS
Tchem
Family:  Enzyme
Novelty:  0.00539046
p_int:  0.987629103
p_ni:  0.012370897
Score:  0.999
Data Source:  BioPlex,STRINGDB
QARS
Tchem
Family:  Enzyme
Novelty:  0.01684657
p_int:  0.979651138
p_ni:  0.020348862
Score:  0.999
Data Source:  BioPlex,STRINGDB
Pathways (9)
Cytosolic tRNA aminoacylation (R-HSA-379716)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic tRNA aminoacylation
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Metabolism of proteins
Reactome
Selenoamino acid metabolism
Name
Explore in Pharos
Explore in Source
Cytosolic tRNA aminoacylation
Metabolism
Metabolism of amino acids and derivatives
Metabolism of proteins
Selenoamino acid metabolism
Gene Ontology Terms (24)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
1
2
42.3
self reported educational attainment
1
1
1
39.6
1
1
0
5.5
15.8
age at onset
1
1
0
5.5
15.8
mathematical ability
1
1
1
8.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
42.3
self reported educational attainment
1
39.6
0
5.5
15.8
age at onset
0
5.5
15.8
mathematical ability
1
8.9
Find similar targets by:
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucyl-tRNA synthetase
VGNC:4066
462167
Mouse
MGI:1913808
107045
Rat
RGD:1304962
291624
Dog
leucyl-tRNA synthetase
VGNC:42592
478051
Horse
leucyl-tRNA synthetase
VGNC:19591
100061092
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucyl-tRNA synthetase
Mouse
Rat
Dog
leucyl-tRNA synthetase
Horse
leucyl-tRNA synthetase
Publication Statistics
PubMed Score 286.46
PubMed score by year
PubTator Score 91.99
PubTator score by year