Tbio CPSF2 Cleavage and polyadenylation specificity factor subunit 2

Protein Summary

Description

Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3' end pre-mRNA processing.

Uniprot Accession IDs

• Q9P2I0
• B3KME1
• Q6NSJ1
• Q9H3W7

Gene Name

• CPSF2

Ensembl ID

• ENST00000298875
• ENSP00000298875
• ENSG00000165934

Symbol

• CPSF100
• KIAA1367
• CPSF100

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.88
histone modification site profile	0.81
virus perturbation	0.76
disease perturbation	0.74
protein domain	0.73

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.21   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 103   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.21   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0