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Tbio
CPSF2
Cleavage and polyadenylation specificity factor subunit 2

Protein Summary
Description
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3' end pre-mRNA processing.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298875
  • ENSP00000298875
  • ENSG00000165934

Symbol
  • CPSF100
  • KIAA1367
  • CPSF100
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.88
histone modification site profile
0.81
virus perturbation
0.76
disease perturbation
0.74
protein domain
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.48   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 103   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.48   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Myopia
1
1
0
1.1
45.7
B-cell acute lymphoblastic leukemia
1
1
0
3.7
1.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Myopia
0
1.1
45.7
B-cell acute lymphoblastic leukemia
0
3.7
1.9
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cleavage and polyadenylation specific factor 2
VGNC:3448
738846
Macaque
cleavage and polyadenylation specific factor 2
697875
Mouse
MGI:1861601
51786
Rat
RGD:1309687
299256
Dog
cleavage and polyadenylation specific factor 2
VGNC:39574
480230
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cleavage and polyadenylation specific factor 2
Macaque
cleavage and polyadenylation specific factor 2
Mouse
Rat
Dog
cleavage and polyadenylation specific factor 2
Pathways (15)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
Processing of Capped Intronless Pre-mRNA
Reactome
Processing of Intronless Pre-mRNAs
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
Processing of Capped Intronless Pre-mRNA
Processing of Intronless Pre-mRNAs
Gene Ontology Terms (11)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (315)
1 – 10 of 315
WDR33
Tbio
Novelty: 0.09221439
p_int: 0.999998369
p_ni: 0.000001631
Score: 0.999
Data Source: BioPlex,STRINGDB
ASB7
Tdark
Novelty: 0.21883348
p_int: 0.99999297
p_ni: 0.00000703
Data Source: BioPlex
SYMPK
Tbio
Novelty: 0.01773552
p_int: 0.999755555
p_ni: 0.000244293
p_wrong: 1.52e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
SRRT
Tbio
Novelty: 0.00429818
p_int: 0.998038848
p_ni: 0.001961152
Score: 0.934
Data Source: BioPlex,STRINGDB
CPSF4
Tbio
Novelty: 0.00206207
p_int: 0.993107898
p_ni: 0.006891304
p_wrong: 7.98e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
FIP1L1
Tbio
Novelty: 0.00520044
p_int: 0.993022404
p_ni: 0.006977597
Score: 0.998
Data Source: BioPlex,STRINGDB
P4HA2
Tbio
Family: Enzyme
Novelty: 0.02097718
p_int: 0.987568004
p_ni: 0.012431996
Data Source: BioPlex
P4HA1
Tchem
Family: Enzyme
Novelty: 0.01624726
p_int: 0.9333362
p_ni: 0.0666638
Data Source: BioPlex
DUSP3
Tchem
Family: Enzyme
Novelty: 0.00518547
p_int: 0.87791444
p_ni: 0.122065845
p_wrong: 0.000019716
Data Source: BioPlex
CPSF3
Tchem
Novelty: 0.01880576
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  16.48

PubMed score by year
PubTator Score  11.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer