USP35
Ubiquitin carboxyl-terminal hydrolase 35
Protein Summary
This gene encodes a member of the peptidase C19 family of ubiquitin-specific proteases. These deubiquitinating enzymes (DUBs) catalyze the removal of ubiquitin proteins from other proteins. The encoded protein associates with polarized mitochondria and has been shown to inhibit NF-kappa B activation and delay PARK2-mediated degradation of mitochondria. Expression of this gene is upregulated by the let-7a microRNA and reduced expression has been observed in human tumor tissues. [provided by RefSeq, Jul 2017]
- ENST00000526425
- ENSP00000434942
- ENSG00000118369
- ENST00000529308
- ENSP00000431876
- KIAA1372
- USP34
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cellular component | 0.84 | ||
virus perturbation | 0.83 | ||
cell line | 0.75 | ||
histone modification site profile | 0.71 | ||
protein domain | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14.32 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 73 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14.32 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 73 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (43)
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (4)
Functions (2)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | FlyBase | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (11)
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
glomerular filtration rate | 2 | 1 | 2 | 71.2 | |||||
total cholesterol measurement | 1 | 1 | 1 | 62.1 | |||||
serum alanine aminotransferase measurement | 2 | 2 | 1 | 6.2 | 54.2 | ||||
1 | 1 | 0 | 1.3 | 44.2 | |||||
L lactate dehydrogenase measurement | 1 | 1 | 1 | 40.7 | |||||
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
glomerular filtration rate | 2 | 71.2 | |||||
total cholesterol measurement | 1 | 62.1 | |||||
serum alanine aminotransferase measurement | 1 | 6.2 | 54.2 | ||||
0 | 1.3 | 44.2 | |||||
L lactate dehydrogenase measurement | 1 | 40.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | ubiquitin specific peptidase 35 | 700073 | ||||||
Mouse | MGI:2685339 | 244144 | ||||||
Rat | RGD:1565984 | 308834 | ||||||
Dog | ubiquitin specific peptidase 35 | VGNC:48191 | 485168 | |||||
Cow | ubiquitin specific peptidase 35 | VGNC:36725 | 525702 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | ubiquitin specific peptidase 35 | |||||
Mouse | ||||||
Rat | ||||||
Dog | ubiquitin specific peptidase 35 | |||||
Cow | ubiquitin specific peptidase 35 | |||||
Publication Statistics
PubMed Score 14.32
PubMed score by year
PubTator Score 7.77
PubTator score by year
Related Publications
Text Mined References (14)
GeneRif Annotations (5)
Items per page:
0 of 0
PMID | Year | Title |
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