Tbio IFT80 Intraflagellar transport protein 80 homolog

Protein Summary

Description

Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia. The protein encoded by this gene is part of the intraflagellar transport complex B and is necessary for the function of motile and sensory cilia. Defects in this gene are a cause of asphyxiating thoracic dystrophy 2 (ATD2). Three transcript variants encoding two different isoforms have been found for this gene.[provided by RefSeq, Jun 2010]

Uniprot Accession IDs

• Q9P2H3
• B4E0K1
• C9J8I0
• Q3MJC4
• Q86YF4
• Q9UIX1

Gene Name

• IFT80

Ensembl ID

• ENST00000326448
• ENSP00000312778
• ENSG00000068885
• ENST00000483465
• ENSP00000418196
• ENST00000496589
• ENSP00000420646

Symbol

• KIAA1374
• WDR56
• ATD2
• SRTD2
• WDR56

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.9
transcription factor binding site profile	0.75
transcription factor perturbation	0.74
cellular component	0.68
tissue sample	0.64

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.06   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 71   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.06   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 71   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (112)

Explore Interacting Targets

1 – 10 of 112

• See Interactions on String-DB

IFT27

Tbio

Family:  Enzyme

Novelty:  0.05592902

p_int:  0.999999992

p_ni:  7e-9

Score:  0.98

Data Source:  BioPlex,STRINGDB

IFT57

Tbio

Novelty:  0.03373199

p_int:  0.999999965

p_ni:  2e-9

p_wrong:  3.3e-8

Score:  0.998

Data Source:  BioPlex,STRINGDB

IFT22

Tbio

Family:  Enzyme

Novelty:  0.18342877

p_int:  0.999999957

p_ni:  4.3e-8

Score:  0.981

Data Source:  BioPlex,STRINGDB

TTC30A

Tdark

Novelty:  1.41742212

p_int:  0.999999871

p_ni:  1.24e-7

p_wrong:  5e-9

Score:  0.992

Data Source:  BioPlex,STRINGDB

CORO1A

Tbio

Novelty:  0.00898925

p_int:  0.999998933

p_ni:  0.000001062

p_wrong:  5e-9

Score:  0.825

Data Source:  BioPlex,STRINGDB

TTC30B

Tbio

Novelty:  0.10944566

p_int:  0.999998391

p_ni:  6.6e-7

p_wrong:  9.49e-7

Score:  0.99

Data Source:  BioPlex,STRINGDB

ABTB2

Tdark

Novelty:  0.45729157

p_int:  0.999993731

p_ni:  0.000006268

p_wrong:  1e-9

Data Source:  BioPlex

FGF8

Tbio

Novelty:  0.00155113

p_int:  0.999940408

p_ni:  0.000048383

p_wrong:  0.000011209

Score:  0.239

Data Source:  BioPlex,STRINGDB

IFT88

Tbio

Novelty:  0.00727114

Score:  0.997

Data Source:  STRINGDB

IFT140

Tbio

Novelty:  0.02872897

Score:  0.994

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (6)

Reactome (3)

WikiPathways (3)

Cilium Assembly (R-HSA-5617833)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cilium Assembly	187 targets	R-HSA-5617833
Reactome	Intraflagellar transport	41 targets	R-HSA-5620924
Reactome	Organelle biogenesis and maintenance	276 targets	R-HSA-1852241

Name	Explore in Pharos	Explore in Source
Cilium Assembly	187 targets	R-HSA-5617833
Intraflagellar transport	41 targets	R-HSA-5620924
Organelle biogenesis and maintenance	276 targets	R-HSA-1852241

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (14)

Components (5)

Processes (9)

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GO Term	Evidence	Assigned by
centrosome	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
cilium	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
intraciliary transport particle B	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
ciliary tip	Traceable Author Statement (TAS)	Reactome
cytoplasm	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell

Disease Associations (null)

No disease associations found

GWAS Traits (11)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 11

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
serum gamma-glutamyl transferase measurement	EFO_0004532	2	2	2		91.1
Oral ulcer	HP_0000155	1	2	0	1.2	88.2
serum alanine aminotransferase measurement	EFO_0004735	2	2	1	7.5	86.2
type II diabetes mellitus	EFO_0001360	2	2	2		71.4
low density lipoprotein cholesterol measurement	EFO_0004611	2	2	2		68.5

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 11

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
serum gamma-glutamyl transferase measurement	EFO_0004532	2		91.1
Oral ulcer	HP_0000155	0	1.2	88.2
serum alanine aminotransferase measurement	EFO_0004735	1	7.5	86.2
type II diabetes mellitus	EFO_0001360	2		71.4
low density lipoprotein cholesterol measurement	EFO_0004611	2		68.5

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Cell projection
Ciliopathy
Cilium
Complete proteome
Cytoplasm
Cytoskeleton
Disease mutation
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein A 1 measurement
aspartate aminotransferase measurement
eosinophil percentage of leukocytes
high density lipoprotein cholesterol measurement
low density lipoprotein cholesterol measurement
monocyte count
Oral ulcer
serum alanine aminotransferase measurement
serum gamma-glutamyl transferase measurement
total cholesterol measurement

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
craniofacial phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
limbs/digits/tail phenotype
mortality/aging
skeleton phenotype

IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	intraflagellar transport 80		705146
Mouse	intraflagellar transport 80	MGI:1915509	68259
Rat	intraflagellar transport 80	RGD:1312006	295106
Dog	intraflagellar transport 80		488132
Horse	intraflagellar transport 80		100049959

Species	Name	OMA	EggNOG	Inparanoid
Macaque	intraflagellar transport 80
Mouse	intraflagellar transport 80
Rat	intraflagellar transport 80
Dog	intraflagellar transport 80
Horse	intraflagellar transport 80

Publication Statistics

PubMed Score 24.06

PubMed score by year

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PubTator Score 13.02

PubTator score by year

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Related Publications

Text Mined References (11)

GeneRif Annotations (4)

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PMID	Year	Title