IFT80
Intraflagellar transport protein 80 homolog
Protein Summary
Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia. The protein encoded by this gene is part of the intraflagellar transport complex B and is necessary for the function of motile and sensory cilia. Defects in this gene are a cause of asphyxiating thoracic dystrophy 2 (ATD2). Three transcript variants encoding two different isoforms have been found for this gene.[provided by RefSeq, Jun 2010]
- ENST00000326448
- ENSP00000312778
- ENSG00000068885
- ENST00000483465
- ENSP00000418196
- ENST00000496589
- ENSP00000420646
- KIAA1374
- WDR56
- ATD2
- SRTD2
- WDR56
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.9 | ||
transcription factor binding site profile | 0.75 | ||
transcription factor perturbation | 0.74 | ||
cellular component | 0.68 | ||
tissue sample | 0.64 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 21.82 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 71 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 21.82 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 71 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
Oral ulcer | 1 | 1 | 0 | 1.2 | 94.2 | ||||
low density lipoprotein cholesterol measurement | 2 | 2 | 2 | 91.2 | |||||
high density lipoprotein cholesterol measurement | 1 | 1 | 1 | 16.2 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
Oral ulcer | 0 | 1.2 | 94.2 | ||||
low density lipoprotein cholesterol measurement | 2 | 91.2 | |||||
high density lipoprotein cholesterol measurement | 1 | 16.2 | |||||
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | intraflagellar transport 80 | 705146 | ||||||
Mouse | MGI:1915509 | 68259 | ||||||
Rat | RGD:1312006 | 295106 | ||||||
Dog | intraflagellar transport 80 | 488132 | ||||||
Horse | intraflagellar transport 80 | 100049959 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | intraflagellar transport 80 | |||||
Mouse | ||||||
Rat | ||||||
Dog | intraflagellar transport 80 | |||||
Horse | intraflagellar transport 80 | |||||
Protein Structure (0 Structures, 1 AlphaFold Model)
Pathways (6)
Reactome (3)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 3 of 3
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cilium Assembly | ||||
Reactome | Intraflagellar transport | ||||
Reactome | Organelle biogenesis and maintenance | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cilium Assembly | ||||
Intraflagellar transport | ||||
Organelle biogenesis and maintenance | ||||
Gene Ontology Terms (14)
Components (5)
Processes (9)
Items per page:
10
1 – 5 of 5
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-SubCell | |||
Protein-Protein Interactions (112)
1 – 10 of 112
IFT27
Family: Enzyme
Novelty: 0.05592902
p_int: 0.999999992
p_ni: 7e-9
Score: 0.98
Data Source: BioPlex,STRINGDB
IFT57
Novelty: 0.03373199
p_int: 0.999999965
p_ni: 2e-9
p_wrong: 3.3e-8
Score: 0.998
Data Source: BioPlex,STRINGDB
IFT22
Family: Enzyme
Novelty: 0.18342877
p_int: 0.999999957
p_ni: 4.3e-8
Score: 0.981
Data Source: BioPlex,STRINGDB
TTC30A
Novelty: 1.41742212
p_int: 0.999999871
p_ni: 1.24e-7
p_wrong: 5e-9
Score: 0.992
Data Source: BioPlex,STRINGDB
CORO1A
Novelty: 0.00898925
p_int: 0.999998933
p_ni: 0.000001062
p_wrong: 5e-9
Score: 0.825
Data Source: BioPlex,STRINGDB
TTC30B
Novelty: 0.10944566
p_int: 0.999998391
p_ni: 6.6e-7
p_wrong: 9.49e-7
Score: 0.99
Data Source: BioPlex,STRINGDB
ABTB2
Novelty: 0.45729157
p_int: 0.999993731
p_ni: 0.000006268
p_wrong: 1e-9
Data Source: BioPlex
FGF8
Novelty: 0.00155113
p_int: 0.999940408
p_ni: 0.000048383
p_wrong: 0.000011209
Score: 0.239
Data Source: BioPlex,STRINGDB
IFT88
Novelty: 0.00727114
Score: 0.997
Data Source: STRINGDB
IFT140
Novelty: 0.02872897
Score: 0.994
Data Source: STRINGDB
Publication Statistics
PubMed Score 21.82
PubMed score by year
PubTator Score 13.02
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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