You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SIPA1L2
Signal-induced proliferation-associated 1-like protein 2

Protein Summary
Description
This gene encodes a member of the signal-induced proliferation-associated 1 like family. Members of this family contain a GTPase activating domain, a PDZ domain and a C-terminal coiled-coil domain with a leucine zipper. A similar protein in rat acts as a GTPases for the small GTPase Rap. [provided by RefSeq, Sep 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262861
  • ENSP00000262861
  • ENSG00000116991
  • ENST00000308942
  • ENSP00000309102
  • ENST00000366630
  • ENSP00000355589

Symbol
  • KIAA1389
  • SPAL2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.67
microRNA
0.65
PubMedID
0.65
disease perturbation
0.62
trait
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.18   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 120   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.18   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
0
1.1
56.2
serum gamma-glutamyl transferase measurement
1
1
1
28.8
comparative body size at age 10, self-reported
1
1
1
27.3
cerebrospinal fluid biomarker measurement
1
1
0
62.7
0.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
56.2
serum gamma-glutamyl transferase measurement
1
28.8
comparative body size at age 10, self-reported
1
27.3
cerebrospinal fluid biomarker measurement
0
62.7
0.1
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
signal induced proliferation associated 1 like 2
VGNC:9900
457821
Mouse
MGI:2676970
244668
Rat
RGD:1306269
361442
Dog
signal induced proliferation associated 1 like 2
VGNC:46181
488969
Horse
signal induced proliferation associated 1 like 2
VGNC:22986
100060169
Species
Name
OMA
EggNOG
Inparanoid
Chimp
signal induced proliferation associated 1 like 2
Mouse
Rat
Dog
signal induced proliferation associated 1 like 2
Horse
signal induced proliferation associated 1 like 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9P2F8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (2)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (79)
1 – 10 of 79
N4BP3
Tdark
Novelty:  0.53420823
p_int:  0.999998386
p_ni:  0.000001613
p_wrong:  1e-9
Score:  0.225
Data Source:  BioPlex,STRINGDB
SIPA1L1
Tdark
Novelty:  0.13134052
p_int:  0.999988325
p_ni:  0.000011675
Data Source:  BioPlex
LZTS2
Tbio
Novelty:  0.09515452
p_int:  0.999981139
p_ni:  0.000018297
p_wrong:  5.64e-7
Score:  0.499
Data Source:  BioPlex,STRINGDB
RACGAP1
Tbio
Family:  Enzyme
Novelty:  0.01197099
p_int:  0.999960564
p_ni:  0.000039434
p_wrong:  1e-9
Score:  0.215
Data Source:  BioPlex,STRINGDB
APOBEC3D
Tbio
Novelty:  0.01102619
p_int:  0.999765944
p_ni:  0.000234034
p_wrong:  2.3e-8
Data Source:  BioPlex
TSPYL1
Tbio
Novelty:  0.06381144
p_int:  0.999685483
p_ni:  0.000314513
p_wrong:  4e-9
Data Source:  BioPlex
NXF2
Tbio
Novelty:  0.04733504
p_int:  0.99928958
p_ni:  0.000708398
p_wrong:  0.000002023
Data Source:  BioPlex
SIPA1L3
Tbio
Novelty:  0.13962558
p_int:  0.999046062
p_ni:  0.000953934
p_wrong:  5e-9
Data Source:  BioPlex
PRG2
Tbio
Novelty:  0.00548995
p_int:  0.998505014
p_ni:  0.001494986
Data Source:  BioPlex
C6orf141
Tdark
Novelty:  1.46022784
p_int:  0.99651238
p_ni:  0.003478444
p_wrong:  0.000009176
Data Source:  BioPlex
Publication Statistics
PubMed Score  5.18

PubMed score by year
PubTator Score  3.28

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer