Tbio RRBP1 Ribosome-binding protein 1

Protein Summary

Description

Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. This gene encodes a ribosome-binding protein of the endoplasmic reticulum (ER) membrane. Studies suggest that this gene plays a role in ER proliferation, secretory pathways and secretory cell differentiation, and mediation of ER-microtubule interactions. Alternative splicing has been observed and protein isoforms are characterized by regions of N-terminal decapeptide and C-terminal heptad repeats. Splicing of the tandem repeats results in variations in ribosome-binding affinity and secretory function. The full-length nature of variants which differ in repeat length has not been determined. Pseudogenes of this gene have been identified on chromosomes 3 and 7, and RRBP1 has been excluded as a candidate gene in the cause of Alagille syndrome, the result of a mutation in a nearby gene on chromosome 20p12. [provided by RefSeq, Apr 2012]

Uniprot Accession IDs

• Q9P2E9
• A0A0A0MRV0
• A2A2S6
• A6NCN6
• O75300
• O75301
• Q5W165
• Q96SB2
• Q9BWP1
• Q9H476

Gene Name

• RRBP1

Ensembl ID

• ENST00000246043
• ENSP00000246043
• ENSG00000125844
• ENST00000360807
• ENSP00000354045
• ENST00000377807
• ENSP00000367038
• ENST00000377813
• ENSP00000367044

Symbol

• KIAA1398
• RRp
• hES
• ES130
• ES/130

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.94
transcription factor perturbation	0.91
ligand (protein) perturbation	0.83
small molecule perturbation	0.75
transcription factor binding site profile	0.73

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.9   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 215   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.9   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0