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Tbio
RRBP1
Ribosome-binding protein 1

Protein Summary
Description
Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. This gene encodes a ribosome-binding protein of the endoplasmic reticulum (ER) membrane. Studies suggest that this gene plays a role in ER proliferation, secretory pathways and secretory cell differentiation, and mediation of ER-microtubule interactions. Alternative splicing has been observed and protein isoforms are characterized by regions of N-terminal decapeptide and C-terminal heptad repeats. Splicing of the tandem repeats results in variations in ribosome-binding affinity and secretory function. The full-length nature of variants which differ in repeat length has not been determined. Pseudogenes of this gene have been identified on chromosomes 3 and 7, and RRBP1 has been excluded as a candidate gene in the cause of Alagille syndrome, the result of a mutation in a nearby gene on chromosome 20p12. [provided by RefSeq, Apr 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000246043
  • ENSP00000246043
  • ENSG00000125844
  • ENST00000360807
  • ENSP00000354045
  • ENST00000377807
  • ENSP00000367038
  • ENST00000377813
  • ENSP00000367044

Symbol
  • KIAA1398
  • RRp
  • hES
  • ES130
  • ES/130
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.94
transcription factor perturbation
0.91
ligand (protein) perturbation
0.83
small molecule perturbation
0.75
transcription factor binding site profile
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.43   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 215   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.43   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (51)
1 – 10 of 51
SYNJ2BP
Tbio
Novelty:  0.02520087
p_int:  0.999802131
p_ni:  0.000197869
Score:  0.404
Data Source:  BioPlex,STRINGDB
ZWINT
Tbio
Novelty:  0.02153276
p_int:  0.998540187
p_ni:  0.001459813
Score:  0.89
Data Source:  BioPlex,STRINGDB
EMILIN1
Tbio
Novelty:  0.02550566
p_int:  0.990339558
p_ni:  0.009660442
Score:  0.23
Data Source:  BioPlex,STRINGDB
EEF1D
Tbio
Novelty:  0.02480745
p_int:  0.989588858
p_ni:  0.010411142
Score:  0.207
Data Source:  BioPlex,STRINGDB
KLHL2
Tbio
Novelty:  0.07279226
p_int:  0.857011117
p_ni:  0.142988883
Data Source:  BioPlex
TSPYL6
Tdark
Novelty:  0.68478376
p_int:  0.77757812
p_ni:  0.222421879
p_wrong:  1e-9
Data Source:  BioPlex
RBMS1
Tbio
Novelty:  0.00520684
Score:  0.826
Data Source:  STRINGDB
RAB8A
Tbio
Family:  Enzyme
Novelty:  0.00486694
Score:  0.82
Data Source:  STRINGDB
PIN4
Tbio
Family:  Enzyme
Novelty:  0.01193983
Score:  0.82
Data Source:  STRINGDB
PQBP1
Tbio
Novelty:  0.01631148
Score:  0.819
Data Source:  STRINGDB
Pathways (2)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Protein processing in endoplasmic reticulum
Name
Explore in Pharos
Explore in Source
Protein processing in endoplasmic reticulum
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
2
2
84.1
apolipoprotein A 1 measurement
2
1
2
77.7
high density lipoprotein cholesterol measurement
2
1
2
67.1
myeloperoxidase measurement
1
1
1
64.9
heel bone mineral density
2
2
2
50.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
84.1
apolipoprotein A 1 measurement
2
77.7
high density lipoprotein cholesterol measurement
2
67.1
myeloperoxidase measurement
1
64.9
heel bone mineral density
2
50.4
Find similar targets by:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosome binding protein 1
VGNC:14479
100613210
Macaque
ribosome binding protein 1
698019
Mouse
MGI:1932395
81910
Rat
RGD:1306536
311483
Dog
ribosome binding protein 1
VGNC:45757
403809
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosome binding protein 1
Macaque
ribosome binding protein 1
Mouse
Rat
Dog
ribosome binding protein 1
Publication Statistics
PubMed Score 70.43
PubMed score by year
PubTator Score 42.23
PubTator score by year