Tbio PCDH10 Protocadherin-10

Protein Summary

Description

Potential calcium-dependent cell-adhesion protein. This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. This family member contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical cadherins. The encoded protein is a cadherin-related neuronal receptor thought to function in the establishment of specific cell-cell connections in the brain. This gene plays a role in inhibiting cancer cell motility and cell migration. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015]

Uniprot Accession IDs

• Q9P2E7
• Q4W5F6
• Q96SF0

Gene Name

• PCDH10

Ensembl ID

• ENST00000264360
• ENSP00000264360
• ENSG00000138650
• ENST00000618019
• ENSP00000480512

Symbol

• KIAA1400
• PCDH19
• OL-PCDH

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.81
trait	0.75
transcription factor perturbation	0.74
virus perturbation	0.72
microRNA	0.69

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.51   (req: < 5)

Gene RIFs: 51   (req: <= 3)

Antibodies: 143   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.51   (req: >= 5)

Gene RIFs: 51   (req: > 3)

Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0