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Tbio
UNC79
Protein unc-79 homolog

Protein Summary
Description
Component of the NALCN sodium channel complex, a cation channel activated either by neuropeptides substance P or neurotensin that controls neuronal excitability. The NALCN channel is responsible for Na(+) leak currents. The protein encoded by this gene, along with UNC80, is an accessory subunit of the NALCN channel that contributes to the Ca(2+) sensitivity of the channel. [provided by RefSeq, Sep 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256339
  • ENSP00000256339
  • ENSG00000133958
  • ENST00000393151
  • ENSP00000376858
  • ENST00000553484
  • ENSP00000451360
  • ENST00000615108
  • ENSP00000479521
  • ENSG00000276416
  • ENST00000621021
  • ENSP00000480937
  • ENST00000627404
  • ENSP00000487436
  • ENST00000627695
  • ENSP00000485969
  • ENST00000629588
  • ENSP00000486167

Symbol
  • KIAA1409
  • KIAA1409
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.63
tissue sample
0.6
histone modification site profile
0.58
cell type or tissue
0.52
phenotype
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.01   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 26   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.01   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 26   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (21)
Items per page:
1 – 5 of 21
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
6
5
6
98.8
body mass index
5
4
5
98.8
mathematical ability
4
3
4
95.3
mathematical ability
4
3
4
95.3
visceral adipose tissue measurement
1
1
1
85.9
Items per page:
1 – 5 of 21
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
6
98.8
body mass index
5
98.8
mathematical ability
4
95.3
mathematical ability
4
95.3
visceral adipose tissue measurement
1
85.9
Pathways (3)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
Transport of small molecules
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (72)
1 – 10 of 72
UNC80
Tbio
Novelty: 0.0667723
Score: 0.998
Data Source: Reactome,STRINGDB
NALCN
Tchem
Family: IC
Novelty: 0.01522178
Score: 0.994
Data Source: Reactome,STRINGDB
FAM155A
Tdark
Novelty: 0.2329396
Score: 0.743
Data Source: STRINGDB
UNC119
Tchem
Novelty: 0.00396292
Score: 0.693
Data Source: STRINGDB
PSMD1
Tbio
Family: Enzyme
Novelty: 0.02168311
Score: 0.631
Data Source: STRINGDB
STOML1
Tbio
Novelty: 0.05746576
Score: 0.631
Data Source: STRINGDB
TMTC4
Tdark
Novelty: 0.53734704
Score: 0.609
Data Source: STRINGDB
KCNMA1
Tclin
Family: IC
Novelty: 0.00088182
Score: 0.591
Data Source: STRINGDB
EIF4ENIF1
Tbio
Novelty: 0.03835664
Score: 0.586
Data Source: STRINGDB
PCLO
Tbio
Novelty: 0.00918397
Score: 0.581
Data Source: STRINGDB
Publication Statistics
PubMed Score  17.01

PubMed score by year
PubTator Score  5.57

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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