Tbio UNC79 Protein unc-79 homolog

Protein Summary

Description

Component of the NALCN sodium channel complex, a cation channel activated either by neuropeptides substance P or neurotensin that controls neuronal excitability. The NALCN channel is responsible for Na(+) leak currents. The protein encoded by this gene, along with UNC80, is an accessory subunit of the NALCN channel that contributes to the Ca(2+) sensitivity of the channel. [provided by RefSeq, Sep 2016]

Uniprot Accession IDs

• Q9P2D8
• B5MDL6
• Q6ZUT7

Gene Name

• UNC79

Ensembl ID

• ENST00000256339
• ENSP00000256339
• ENSG00000133958
• ENST00000393151
• ENSP00000376858
• ENST00000553484
• ENSP00000451360
• ENST00000615108
• ENSP00000479521
• ENSG00000276416
• ENST00000621021
• ENSP00000480937
• ENST00000627404
• ENSP00000487436
• ENST00000627695
• ENSP00000485969
• ENST00000629588
• ENSP00000486167

Symbol

• KIAA1409
• KIAA1409

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell line	0.63
tissue sample	0.6
histone modification site profile	0.58
cell type or tissue	0.52
phenotype	0.52

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.93   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 26   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.93   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 26   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0