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Tbio
DNAH1
Dynein heavy chain 1, axonemal

Protein Summary
Description
Force generating protein of cilia required for sperm flagellum motility. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required in spermatozoa for the formation of the inner dynein arms and biogenesis of the axoneme (PubMed:24360805). This gene encodes an inner dynein arm heavy chain that provides structural support between the radial spokes and the outer doublet of the sperm tail. Naturally occurring mutations in this gene are associated with primary ciliary dyskinesia and multiple morphological anomalies of the flagella that result in asthenozoospermia and male infertility. Mice with a homozygous knockout of the orthologous gene are viable but have reduced sperm motility and are infertile. [provided by RefSeq, Feb 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000420323
  • ENSP00000401514
  • ENSG00000114841

Symbol
  • DHC7
  • DNAHC1
  • KIAA1410
  • HL11
  • HDHC7
  • HL-11
  • CILD37
  • DNAHC1
  • HSRF-1
  • SPGF18
  • XLHSRF-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
molecular function
0.93
gene perturbation
0.68
kinase perturbation
0.6
interacting protein
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.09   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 44   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.09   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 44   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
worry measurement
1
1
1
55.3
high density lipoprotein cholesterol measurement
1
1
1
51.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
worry measurement
1
55.3
high density lipoprotein cholesterol measurement
1
51.7
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dynein axonemal heavy chain 1
VGNC:8833
460422
Macaque
dynein axonemal heavy chain 1
697401
Mouse
MGI:107721
110084
Rat
RGD:621795
171339
Dog
dynein axonemal heavy chain 1
VGNC:40011
476598
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dynein axonemal heavy chain 1
Macaque
dynein axonemal heavy chain 1
Mouse
Rat
Dog
dynein axonemal heavy chain 1
Protein Structure (0 Structures, 16 AlphaFold Models)
RepresentationColor Scheme

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (19)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (100)
1 – 10 of 100
DNAH14
Tdark
Novelty: 0.28289652
Score: 0.954
Data Source: STRINGDB
DNAH12
Tbio
Novelty: 0.02743114
Score: 0.954
Data Source: STRINGDB
DCTN1
Tbio
Novelty: 0.00494896
Score: 0.942
Data Source: STRINGDB
PAFAH1B1
Tbio
Family: Enzyme
Novelty: 0.00256206
Score: 0.941
Data Source: STRINGDB
CLIP1
Tbio
Novelty: 0.00399891
Score: 0.935
Data Source: STRINGDB
DCTN2
Tbio
Novelty: 0.01045432
Score: 0.934
Data Source: STRINGDB
DYNC1LI1
Tbio
Novelty: 0.02164556
Score: 0.934
Data Source: STRINGDB
DYNLT3
Tbio
Novelty: 0.10969629
Score: 0.934
Data Source: STRINGDB
DNAH17
Tdark
Novelty: 0.14878692
Score: 0.92
Data Source: STRINGDB
DNAH3
Tdark
Novelty: 0.0628368
Score: 0.918
Data Source: STRINGDB
Publication Statistics
PubMed Score  24.09

PubMed score by year
PubTator Score  20.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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