Tbio DNAH1 Dynein heavy chain 1, axonemal

Protein Summary

Description

Force generating protein of cilia required for sperm flagellum motility. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required in spermatozoa for the formation of the inner dynein arms and biogenesis of the axoneme (PubMed:24360805). This gene encodes an inner dynein arm heavy chain that provides structural support between the radial spokes and the outer doublet of the sperm tail. Naturally occurring mutations in this gene are associated with primary ciliary dyskinesia and multiple morphological anomalies of the flagella that result in asthenozoospermia and male infertility. Mice with a homozygous knockout of the orthologous gene are viable but have reduced sperm motility and are infertile. [provided by RefSeq, Feb 2017]

Uniprot Accession IDs

• Q9P2D7
• B0I1R6
• O00436
• O15435
• O95491
• Q6ZU48
• Q86YK7
• Q8TEJ4
• Q92863
• Q9H8E6
• Q9UFW6
• Q9Y4Z7

Gene Name

• DNAH1

Ensembl ID

• ENST00000420323
• ENSP00000401514
• ENSG00000114841

Symbol

• DHC7
• DNAHC1
• KIAA1410
• HL11
• HDHC7
• HL-11
• CILD37
• DNAHC1
• HSRF-1
• SPGF18
• XLHSRF-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
molecular function	0.93
gene perturbation	0.68
kinase perturbation	0.6
interacting protein	0.59

Protein Classes

PANTHER Classes

Protein / Hydrolase / Dynein Heavy Chain 1, Axonemal

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Microtubule Binding Motor Protein / Dynein Heavy Chain 1, Axonemal

DTO Classes

Protein / Enzyme / Hydrolase / Dynein Heavy Chain 1, Axonemal

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.29   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 44   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.29   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 44   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0