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Tdark
COPZ2
Coatomer subunit zeta-2

Protein Summary
Description
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex (By similarity). This gene encodes a member of the adaptor complexes small subunit family. The encoded protein is a subunit of the coatomer protein complex, a seven-subunit complex that functions in the formation of COPI-type, non-clathrin-coated vesicles. COPI vesicles function in the retrograde Golgi-to-ER transport of dilysine-tagged proteins. [provided by RefSeq, Feb 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000621465
  • ENSP00000480707
  • ENSG00000005243

Symbol
  • zeta2-COP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
virus perturbation
0.72
cellular component
0.71
gene perturbation
0.69
PubMedID
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.41   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 62   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.41   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 62   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
4
4
80.1
BMI-adjusted hip circumference
2
3
4
76.5
triglyceride measurement
3
2
3
75.4
hemoglobin measurement
1
1
1
72.9
hematocrit
1
1
1
63.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
4
80.1
BMI-adjusted hip circumference
4
76.5
triglyceride measurement
3
75.4
hemoglobin measurement
1
72.9
hematocrit
1
63.4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coatomer protein complex subunit zeta 2
VGNC:9245
101057422
Macaque
coatomer protein complex subunit zeta 2
696299
Mouse
MGI:1929008
56358
Rat
RGD:1306948
360611
Dog
coatomer protein complex subunit zeta 2
VGNC:39515
491050
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coatomer protein complex subunit zeta 2
Macaque
coatomer protein complex subunit zeta 2
Mouse
Rat
Dog
coatomer protein complex subunit zeta 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9P299-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (11)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
COPI-mediated anterograde transport
Reactome
ER to Golgi Anterograde Transport
Reactome
Golgi-to-ER retrograde transport
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPI-dependent Golgi-to-ER retrograde traffic
COPI-mediated anterograde transport
ER to Golgi Anterograde Transport
Golgi-to-ER retrograde transport
Gene Ontology Terms (11)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (187)
1 – 10 of 187
COPG1
Tbio
Novelty:  0.01331193
p_int:  0.99971372
p_ni:  0.00028628
Score:  0.984
Data Source:  BioPlex,Reactome,STRINGDB
SNX17
Tbio
Novelty:  0.03960737
p_int:  0.995390637
p_ni:  0.004609363
Data Source:  BioPlex
RDH13
Tbio
Family:  Enzyme
Novelty:  0.20184998
p_int:  0.993701667
p_ni:  0.006293744
p_wrong:  0.000004589
Data Source:  BioPlex
COPB1
Tbio
Novelty:  0.0078407
p_int:  0.961327447
p_ni:  0.038672553
Score:  0.988
Data Source:  BioPlex,Reactome,STRINGDB
COPA
Tbio
Novelty:  0.02712824
p_int:  0.956260222
p_ni:  0.043739778
Score:  0.974
Data Source:  BioPlex,Reactome,STRINGDB
COPB2
Tbio
Novelty:  0.02705751
p_int:  0.955900792
p_ni:  0.044099208
Score:  0.987
Data Source:  BioPlex,Reactome,STRINGDB
HSPA9
Tchem
Novelty:  0.00235171
p_int:  0.833808246
p_ni:  0.166191754
Data Source:  BioPlex
COPE
Tbio
Novelty:  0.02037359
p_int:  0.793912577
p_ni:  0.206087423
Score:  0.983
Data Source:  BioPlex,Reactome,STRINGDB
ARCN1
Tbio
Novelty:  0.06716916
Score:  0.994
Data Source:  Reactome,STRINGDB
COPG2
Tbio
Novelty:  0.06126837
Score:  0.986
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  4.41

PubMed score by year
PubTator Score  2.18

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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