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Tdark
HIGD1B
HIG1 domain family member 1B

Protein Summary
Description
This gene encodes a member of the hypoxia inducible gene 1 (HIG1) domain family. The encoded protein is localized to the cell membrane and has been linked to tumorigenesis and the progression of pituitary adenomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253410
  • ENSP00000253410
  • ENSG00000131097
  • ENST00000591513
  • ENSP00000468511

Symbol
  • CLST11240
  • CLST11240-15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.59
tissue sample
0.54
gene perturbation
0.49
tissue
0.47
disease perturbation
0.36


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 33   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 33   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (17)
TMEM141
Tdark
Novelty:  0.62732191
Score:  0.833
Data Source:  STRINGDB
TMEM14A
Tbio
Novelty:  0.15995178
Score:  0.787
Data Source:  STRINGDB
TMEM14C
Tdark
Novelty:  0.10707234
Score:  0.707
Data Source:  STRINGDB
ST18
Tbio
Family:  TF
Novelty:  0.22660628
Score:  0.565
Data Source:  STRINGDB
IFI27L1
Tdark
Novelty:  0.7520707
Score:  0.526
Data Source:  STRINGDB
HPGD
Tchem
Family:  Enzyme
Novelty:  0.00348376
Score:  0.511
Data Source:  STRINGDB
COX5B
Tbio
Family:  Enzyme
Novelty:  0.01729026
Score:  0.509
Data Source:  STRINGDB
COX6A2
Tbio
Family:  Enzyme
Novelty:  0.05368739
Score:  0.459
Data Source:  STRINGDB
COX6A1
Tbio
Family:  Enzyme
Novelty:  0.05543187
Score:  0.459
Data Source:  STRINGDB
IDI1
Tchem
Family:  Enzyme
Novelty:  0.01145181
Score:  0.455
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
biological sex
1
1
1
49.5
electrocardiography
1
1
1
29
self reported educational attainment
1
1
1
15.6
chronotype measurement
1
1
1
6.4
cognitive function measurement
1
1
1
4.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
biological sex
1
49.5
electrocardiography
1
29
self reported educational attainment
1
15.6
chronotype measurement
1
6.4
cognitive function measurement
1
4.6
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
HIG1 hypoxia inducible domain family member 1B
VGNC:9322
454737
Mouse
MGI:1922939
75689
Rat
RGD:1306907
287738
Dog
HIG1 hypoxia inducible domain family member 1B
VGNC:41688
480496
Horse
HIG1 hypoxia inducible domain family member 1B
VGNC:18785
100050651
Species
Name
OMA
EggNOG
Inparanoid
Chimp
HIG1 hypoxia inducible domain family member 1B
Mouse
Rat
Dog
HIG1 hypoxia inducible domain family member 1B
Horse
HIG1 hypoxia inducible domain family member 1B
Publication Statistics
PubMed Score 3.00
PubMed score by year
PubTator Score 4.64
PubTator score by year
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Related Publications
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PMID
Year
Title