Tbio C5AR2 C5a anaphylatoxin chemotactic receptor 2

Protein Summary

Description

Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways. This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

Uniprot Accession IDs

• Q9P296
• B2RA09

Gene Name

• C5AR2

Ensembl ID

• ENST00000595464
• ENSP00000472620
• ENSG00000134830
• ENST00000600626
• ENSP00000471184

Symbol

• C5L2
• GPR77
• C5L2
• GPF77
• GPR77

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.92
cell type or tissue	0.75
biological process	0.73
protein domain	0.73
small molecule perturbation	0.54

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / C5a Anaphylatoxin Chemotactic Receptor 2

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Anaphylatoxin Receptor / C5a Anaphylatoxin Chemotactic Receptor 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.87   (req: < 5)

Gene RIFs: 39   (req: <= 3)

Antibodies: 339   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.87   (req: >= 5)

Gene RIFs: 39   (req: > 3)

Antibodies: 339   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0