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Tbio
C5AR2
C5a anaphylatoxin chemotactic receptor 2

Protein Summary
Description
Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways. This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000595464
  • ENSP00000472620
  • ENSG00000134830
  • ENST00000600626
  • ENSP00000471184

Symbol
  • C5L2
  • GPR77
  • C5L2
  • GPF77
  • GPR77
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.92
cell type or tissue
0.75
biological process
0.73
protein domain
0.73
small molecule perturbation
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.97   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 339   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.97   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 339   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (81)
PTPN2
Tchem
Family:  Enzyme
Novelty:  0.00372891
p_int:  0.999997695
p_ni:  0.000002305
Data Source:  BioPlex
GSTCD
Tbio
Family:  Enzyme
Novelty:  0.11613228
p_int:  0.999982397
p_ni:  0.000016247
p_wrong:  0.000001356
Data Source:  BioPlex
ABHD17A
Tbio
Family:  Enzyme
Novelty:  0.26144756
p_int:  0.999980785
p_ni:  0.000019194
p_wrong:  2.1e-8
Score:  0.181
Data Source:  BioPlex,STRINGDB
ABHD6
Tchem
Family:  Enzyme
Novelty:  0.019314
p_int:  0.999978033
p_ni:  0.000021963
p_wrong:  4e-9
Data Source:  BioPlex
PTPN1
Tchem
Family:  Enzyme
Novelty:  0.00065779
p_int:  0.999970167
p_ni:  0.000029833
Data Source:  BioPlex
DHRS3
Tbio
Family:  Enzyme
Novelty:  0.04448013
p_int:  0.999783713
p_ni:  0.000163553
p_wrong:  0.000052734
Data Source:  BioPlex
TTK
Tchem
Family:  Kinase
Novelty:  0.00447957
p_int:  0.999515371
p_ni:  0.000484629
Data Source:  BioPlex
ABHD17B
Tbio
Family:  Enzyme
Novelty:  0.64360453
p_int:  0.999466379
p_ni:  0.000533619
p_wrong:  2e-9
Score:  0.167
Data Source:  BioPlex,STRINGDB
EVI5L
Tbio
Novelty:  0.70769557
p_int:  0.995838675
p_ni:  0.00411629
p_wrong:  0.000045034
Data Source:  BioPlex
ATP13A3
Tbio
Family:  Transporter
Novelty:  0.13498113
p_int:  0.995769299
p_ni:  0.004230701
p_wrong:  1e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

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Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Complement cascade
Reactome
GPCR ligand binding
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
Complement cascade
GPCR ligand binding
Immune System
Innate Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
2
2
52
body height
1
1
1
21.5
leukocyte count
1
1
1
5.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
52
body height
1
21.5
leukocyte count
1
5.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 97.97
PubMed score by year
PubTator Score 52.81
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title