You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
STK26
Serine/threonine-protein kinase 26

Protein Summary
Description
Mediator of cell growth (PubMed:11641781, PubMed:17360971). Modulates apoptosis (PubMed:11641781, PubMed:17360971). In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394334
  • ENSP00000377867
  • ENSG00000134602
  • ENST00000394335
  • ENSP00000377868
  • ENST00000496850
  • ENSP00000419702

Symbol
  • MASK
  • MST4
  • MASK
  • MST4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.97
histone modification site profile
0.71
gene perturbation
0.69
cellular component
0.67
tissue
0.63


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.33   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 265   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.33   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 265   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
neratinib
chemical structure image
Active Ligands (1)
1 – 1 of 1
CHEMBL3770443
chemical structure image
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serine/threonine kinase 26
VGNC:12544
107971181
Macaque
serine/threonine kinase 26
707739
Mouse
MGI:1917665
70415
Rat
RGD:1563568
317589
Dog
serine/threonine kinase 26
VGNC:46910
492140
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serine/threonine kinase 26
Macaque
serine/threonine kinase 26
Mouse
Rat
Dog
serine/threonine kinase 26
Protein Structure (8 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9P289-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Apoptotic cleavage of cellular proteins
Reactome
Apoptotic execution phase
Reactome
Programmed Cell Death
Name
Explore in Pharos
Explore in Source
Apoptosis
Apoptotic cleavage of cellular proteins
Apoptotic execution phase
Programmed Cell Death
Gene Ontology Terms (31)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (84)
1 – 10 of 84
STK25
Tchem
Family: Kinase
Novelty: 0.03229688
p_int: 0.999999998
p_ni: 2e-9
Score: 0.865
Data Source: BioPlex,STRINGDB
PDCD10
Tbio
Novelty: 0.00683934
p_int: 0.999999996
p_ni: 4e-9
Score: 0.998
Data Source: BioPlex,STRINGDB
PROSER2
Tdark
Novelty: 0.56334611
p_int: 0.999976262
p_ni: 0.000023738
Score: 0.546
Data Source: BioPlex,STRINGDB
C4orf19
Tdark
Novelty: 2.1863624
p_int: 0.999864854
p_ni: 0.000135146
Score: 0.836
Data Source: BioPlex,STRINGDB
BMP7
Tbio
Novelty: 0.00049424
p_int: 0.996874958
p_ni: 0.003125042
Score: 0.523
Data Source: BioPlex,STRINGDB
STRIP2
Tbio
Novelty: 0.19321125
p_int: 0.993247902
p_ni: 0.006752094
p_wrong: 4e-9
Score: 0.961
Data Source: BioPlex,STRINGDB
MAGIX
Tdark
Novelty: 0.38577176
p_int: 0.96064548
p_ni: 0.03935452
Score: 0.16
Data Source: BioPlex,STRINGDB
RGS2
Tbio
Novelty: 0.00370571
p_int: 0.864100195
p_ni: 0.135899805
Score: 0.164
Data Source: BioPlex,STRINGDB
NLRP10
Tbio
Novelty: 0.0472395
p_int: 0.859282941
p_ni: 0.140717044
p_wrong: 1.5e-8
Data Source: BioPlex
FAM174A
Tdark
Novelty: 0.30693139
p_int: 0.855435355
p_ni: 0.144564645
Data Source: BioPlex
Publication Statistics
PubMed Score  31.33

PubMed score by year
PubTator Score  22.39

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer