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Tbio
FNIP2
Folliculin-interacting protein 2

Protein Summary
Description
Acts as a co-chaperone of HSP90AA1. Inhibits the ATPase activity of HSP90AA1 leading to reduction in its chaperone activity. Facilitates the binding of client protein FLCN to HSP90AA1 (PubMed:27353360). May play a role in the signal transduction pathway of apoptosis induced by O6-methylguanine-mispaired lesions (By similarity). May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways (PubMed:18403135). May regulate phosphorylation of RPS6KB1 (PubMed:18663353). This gene encodes a protein that binds to the tumor suppressor folliculin and to AMP-activated protein kinase (AMPK), and may play a role cellular metabolism and nutrient sensing by regulating the AMPK-mechanistic target of rapamycin signaling pathway. The encoded protein may also be involved in regulating the O6-methylguanine-induced apoptosis signaling pathway. This gene has a closely related paralog that encodes a protein with similar binding activities. Both related proteins also associat ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264433
  • ENSP00000264433
  • ENSG00000052795

Symbol
  • FNIPL
  • KIAA1450
  • MAPO1
  • FNIPL
  • MAPO1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.8
histone modification site profile
0.73
gene perturbation
0.68
biological process
0.67
protein domain
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.23   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 150   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.23   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
3
2
6
93.5
metabolite measurement
3
2
3
87.7
self reported educational attainment
4
4
3
5.5
85.1
sex hormone-binding globulin measurement
6
1
6
81.9
mathematical ability
3
2
3
74
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
6
93.5
metabolite measurement
3
87.7
self reported educational attainment
3
5.5
85.1
sex hormone-binding globulin measurement
6
81.9
mathematical ability
3
74
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
folliculin interacting protein 2
VGNC:602
461575
Mouse
MGI:2683054
329679
Rat
RGD:1562174
310538
Dog
folliculin interacting protein 2
VGNC:40936
475482
Horse
folliculin interacting protein 2
VGNC:18093
100069124
Species
Name
OMA
EggNOG
Inparanoid
Chimp
folliculin interacting protein 2
Mouse
Rat
Dog
folliculin interacting protein 2
Horse
folliculin interacting protein 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9P278-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (44)
1 – 10 of 44
LAMTOR5
Tbio
Novelty:  0.003692
p_int:  0.999233954
p_ni:  2.7e-8
p_wrong:  0.00076602
Score:  0.212
Data Source:  BioPlex,STRINGDB
LAMTOR4
Tdark
Novelty:  0.24218646
p_int:  0.998995493
p_ni:  0.000001291
p_wrong:  0.001003216
Score:  0.311
Data Source:  BioPlex,STRINGDB
FLCN
Tbio
Novelty:  0.0022007
Score:  0.99
Data Source:  Reactome,STRINGDB
RRAGC
Tbio
Novelty:  0.01462756
Score:  0.914
Data Source:  STRINGDB
RRAGD
Tbio
Novelty:  0.04742375
Score:  0.899
Data Source:  STRINGDB
FNIP1
Tbio
Novelty:  0.05906465
Score:  0.828
Data Source:  STRINGDB
C4orf45
Tdark
Novelty:  10.95652174
Score:  0.716
Data Source:  STRINGDB
WDR59
Tdark
Novelty:  0.22243351
Score:  0.684
Data Source:  STRINGDB
SEH1L
Tbio
Novelty:  0.03666501
Score:  0.671
Data Source:  STRINGDB
SMCR8
Tbio
Novelty:  0.11500348
Score:  0.651
Data Source:  STRINGDB
Publication Statistics
PubMed Score  8.23

PubMed score by year
PubTator Score  6.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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