Tbio JCAD Junctional protein associated with coronary artery disease

Protein Summary

Description

This gene encodes an endothelial cell-to-cell junction protein. Naturally occurring mutations in this gene are associated with coronary artery disease, late onset alzheimer disease, and emphysema distribution. [provided by RefSeq, Mar 2017]

Uniprot Accession IDs

• Q9P266
• Q5HYA7
• Q5T992
• Q86WZ9
• Q9BYJ2
• JCAD

Gene Name

• JCAD

Ensembl ID

• ENST00000375377
• ENSP00000364526
• ENSG00000165757

Symbol

• KIAA1462
• KIAA1462

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.23   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 24   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.23   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 24   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0