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Tdark
LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

Protein Summary
Description
Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1 (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000248668
  • ENSP00000248668
  • ENSG00000128011

Symbol
  • KIAA1484
  • SALM2
  • SALM2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
tissue sample
0.65
cell line
0.56
gene perturbation
0.53
tissue
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.12   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 68   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.12   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 68   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (59)
VAMP5
Tbio
Novelty:  0.09958312
p_int:  0.998193621
p_ni:  0.001806379
Data Source:  BioPlex
SLC39A5
Tbio
Family:  Transporter
Novelty:  0.05205571
p_int:  0.995535417
p_ni:  0.004464583
Data Source:  BioPlex
TMEM30B
Tbio
Novelty:  0.26735006
p_int:  0.994151693
p_ni:  0.005848307
Data Source:  BioPlex
TMX1
Tbio
Novelty:  0.03444237
p_int:  0.992357484
p_ni:  0.007642516
Score:  0.151
Data Source:  BioPlex,STRINGDB
CCL14
Tbio
Novelty:  0.0103752
p_int:  0.97377609
p_ni:  0.02622391
Score:  0.187
Data Source:  BioPlex,STRINGDB
PCDHGB1
Tdark
Novelty:  0.60440805
p_int:  0.96537572
p_ni:  0.03462428
Data Source:  BioPlex
SCN3B
Tbio
Family:  IC
Novelty:  0.0438123
p_int:  0.942882571
p_ni:  0.057117428
Data Source:  BioPlex
CDH5
Tbio
Novelty:  0.00072649
p_int:  0.927992739
p_ni:  0.07200726
p_wrong:  1e-9
Data Source:  BioPlex
CDCP1
Tbio
Novelty:  0.01385067
p_int:  0.907613817
p_ni:  0.092386183
Score:  0.187
Data Source:  BioPlex,STRINGDB
IFNA21
Tbio
Novelty:  0.00581034
p_int:  0.903199726
p_ni:  0.096800274
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Neuronal System (R-HSA-112316)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Protein-protein interactions at synapses
Reactome
Synaptic adhesion-like molecules
Name
Explore in Pharos
Explore in Source
Neuronal System
Protein-protein interactions at synapses
Synaptic adhesion-like molecules
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
7
3
0
2.2
91.3
remission
3
1
0
2.1
84.2
3
1
0
2.1
84.2
mitochondrial heteroplasmy measurement
1
1
1
56.6
viral load
1
1
1
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
2.2
91.3
remission
0
2.1
84.2
0
2.1
84.2
mitochondrial heteroplasmy measurement
1
56.6
viral load
1
49.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat and fibronectin type III domain containing 1
VGNC:2416
456394
Mouse
MGI:2136810
80749
Rat
RGD:1304707
365222
Dog
leucine rich repeat and fibronectin type III domain containing 1
VGNC:42760
484512
Horse
leucine rich repeat and fibronectin type III domain containing 1
VGNC:19748
100067447
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat and fibronectin type III domain containing 1
Mouse
Rat
Dog
leucine rich repeat and fibronectin type III domain containing 1
Horse
leucine rich repeat and fibronectin type III domain containing 1
Publication Statistics
PubMed Score 4.12
PubMed score by year
PubTator Score 2.36
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title