LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1
Protein Summary
Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1 (By similarity).
- ENST00000248668
- ENSP00000248668
- ENSG00000128011
- KIAA1484
- SALM2
- SALM2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.97 | ||
tissue sample | 0.65 | ||
cell line | 0.56 | ||
gene perturbation | 0.53 | ||
tissue | 0.49 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4.12 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 68 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4.12 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 68 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 1
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (59)
SLC39A5
Family: Transporter
Novelty: 0.05205571
p_int: 0.995535417
p_ni: 0.004464583
Data Source: BioPlex
TMX1
Novelty: 0.03444237
p_int: 0.992357484
p_ni: 0.007642516
Score: 0.151
Data Source: BioPlex,STRINGDB
CCL14
Novelty: 0.0103752
p_int: 0.97377609
p_ni: 0.02622391
Score: 0.187
Data Source: BioPlex,STRINGDB
CDCP1
Novelty: 0.01385067
p_int: 0.907613817
p_ni: 0.092386183
Score: 0.187
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Neuronal System | ||||
Reactome | Protein-protein interactions at synapses | ||||
Reactome | Synaptic adhesion-like molecules | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Neuronal System | ||||
Protein-protein interactions at synapses | ||||
Synaptic adhesion-like molecules | ||||
Viral Interactions (0)
Gene Ontology Terms (5)
Components (4)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
7 | 3 | 0 | 2.2 | 91.3 | |||||
remission | 3 | 1 | 0 | 2.1 | 84.2 | ||||
3 | 1 | 0 | 2.1 | 84.2 | |||||
mitochondrial heteroplasmy measurement | 1 | 1 | 1 | 56.6 | |||||
viral load | 1 | 1 | 1 | 49.5 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 2.2 | 91.3 | |||||
remission | 0 | 2.1 | 84.2 | ||||
0 | 2.1 | 84.2 | |||||
mitochondrial heteroplasmy measurement | 1 | 56.6 | |||||
viral load | 1 | 49.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | leucine rich repeat and fibronectin type III domain containing 1 | VGNC:2416 | 456394 | |||||
Mouse | MGI:2136810 | 80749 | ||||||
Rat | RGD:1304707 | 365222 | ||||||
Dog | leucine rich repeat and fibronectin type III domain containing 1 | VGNC:42760 | 484512 | |||||
Horse | leucine rich repeat and fibronectin type III domain containing 1 | VGNC:19748 | 100067447 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | leucine rich repeat and fibronectin type III domain containing 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | leucine rich repeat and fibronectin type III domain containing 1 | |||||
Horse | leucine rich repeat and fibronectin type III domain containing 1 | |||||
Publication Statistics
PubMed Score 4.12
PubMed score by year
PubTator Score 2.36
PubTator score by year
Related Publications
Text Mined References (3)
GeneRif Annotations (1)
Items per page:
0 of 0
PMID | Year | Title |
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