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Tbio
ZFAT
Zinc finger protein ZFAT

Protein Summary
Description
May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated (By similarity). This gene encodes a protein that likely binds DNA and functions as a transcriptional regulator involved in apoptosis and cell survival. This gene resides in a susceptibility locus for autoimmune thyroid disease (AITD) on chromosome 8q24. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377838
  • ENSP00000367069
  • ENSG00000066827
  • ENST00000520214
  • ENSP00000428483
  • ENST00000520727
  • ENSP00000427831
  • ENST00000523399
  • ENSP00000429091

Symbol
  • KIAA1485
  • ZFAT1
  • ZNF406
  • AITD3
  • ZFAT1
  • ZNF406
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.93
histone modification site profile
0.87
trait
0.86
cell type or tissue
0.84
transcription factor
0.78


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.99   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 38   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.99   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 38   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
3
3
3
91.8
appendicular lean mass
3
2
6
90
BMI-adjusted waist-hip ratio
1
1
1
79.1
mean corpuscular hemoglobin concentration
1
1
1
76.9
red blood cell density measurement
1
1
1
65.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
3
91.8
appendicular lean mass
6
90
BMI-adjusted waist-hip ratio
1
79.1
mean corpuscular hemoglobin concentration
1
76.9
red blood cell density measurement
1
65.3
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger and AT-hook domain containing
VGNC:768
464412
Macaque
zinc finger and AT-hook domain containing
698512
Mouse
MGI:2681865
380993
Rat
RGD:1310886
362925
Dog
zinc finger and AT-hook domain containing
VGNC:48604
482051
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger and AT-hook domain containing
Macaque
zinc finger and AT-hook domain containing
Mouse
Rat
Dog
zinc finger and AT-hook domain containing
Protein Structure (26 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9P243-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 26
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (10)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (35)
1 – 10 of 35
NCAPG
Tbio
Novelty: 0.01777557
Score: 0.772
Data Source: STRINGDB
NFYC
Tbio
Family: TF
Novelty: 0.00626931
Score: 0.688
Data Source: STRINGDB
GPX7
Tbio
Family: Enzyme
Novelty: 0.01342855
Score: 0.642
Data Source: STRINGDB
TMEM247
Tdark
Novelty: 2.01165288
Score: 0.592
Data Source: STRINGDB
TG
Tbio
Novelty: 0.00010111
Score: 0.571
Data Source: STRINGDB
STARD13
Tbio
Novelty: 0.00750938
Score: 0.57
Data Source: STRINGDB
LCORL
Tbio
Family: TF
Novelty: 0.02730877
Score: 0.564
Data Source: STRINGDB
AMELX
Tbio
Novelty: 0.00063284
Score: 0.539
Data Source: STRINGDB
FOXD3
Tbio
Family: TF
Novelty: 0.00550321
Score: 0.534
Data Source: STRINGDB
KLHL29
Tbio
Novelty: 0.72596897
Score: 0.501
Data Source: STRINGDB
Publication Statistics
PubMed Score  30.99

PubMed score by year
PubTator Score  11.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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