ZFAT
Zinc finger protein ZFAT
Protein Summary
May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated (By similarity). This gene encodes a protein that likely binds DNA and functions as a transcriptional regulator involved in apoptosis and cell survival. This gene resides in a susceptibility locus for autoimmune thyroid disease (AITD) on chromosome 8q24. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2009]
- ENST00000377838
- ENSP00000367069
- ENSG00000066827
- ENST00000520214
- ENSP00000428483
- ENST00000520727
- ENSP00000427831
- ENST00000523399
- ENSP00000429091
- KIAA1485
- ZFAT1
- ZNF406
- AITD3
- ZFAT1
- ZNF406
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor binding site profile | 0.93 | ||
histone modification site profile | 0.87 | ||
trait | 0.86 | ||
cell type or tissue | 0.84 | ||
transcription factor | 0.78 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 41.24 (req: < 5)
Gene RIFs: 16 (req: <= 3)
Antibodies: 38 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 41.24 (req: >= 5)
Gene RIFs: 16 (req: > 3)
Antibodies: 38 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0