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Tdark
ATP10D
Probable phospholipid-transporting ATPase VD

Protein Summary
Description
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273859
  • ENSP00000273859
  • ENSG00000145246

Symbol
  • ATPVD
  • KIAA1487
  • ATPVD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
metabolite
0.98
protein domain
0.92
histone modification site profile
0.86
transcription factor perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.57   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 39   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.57   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 39   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (29)
1 – 10 of 29
TMEM86B
Tbio
Family:  Enzyme
Novelty:  0.26982157
Score:  0.793
Data Source:  STRINGDB
TMEM30A
Tbio
Novelty:  0.05115559
Score:  0.746
Data Source:  STRINGDB
SIRPB1
Tbio
Novelty:  0.09889723
Score:  0.714
Data Source:  STRINGDB
SIRPB1
Tbio
Novelty:  0.09889723
Score:  0.714
Data Source:  STRINGDB
COX18
Tbio
Novelty:  0.06288021
Score:  0.663
Data Source:  STRINGDB
NSUN7
Tdark
Family:  Enzyme
Novelty:  0.16082462
Score:  0.663
Data Source:  STRINGDB
TMEM30CP
Tdark
Novelty:  0.4661526
Score:  0.646
Data Source:  STRINGDB
TRIML1
Tdark
Family:  Enzyme
Novelty:  0.63862986
Score:  0.646
Data Source:  STRINGDB
BEND5
Tdark
Novelty:  0.6502216
Score:  0.587
Data Source:  STRINGDB
DPEP2
Tbio
Family:  Enzyme
Novelty:  0.14691384
Score:  0.577
Data Source:  STRINGDB
Pathways (3)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Ion transport by P-type ATPases
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Ion transport by P-type ATPases
Transport of small molecules
Gene Ontology Terms (11)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
1
3
11
84.6
sphingolipid measurement
2
2
2
83.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
11
84.6
sphingolipid measurement
2
83.4
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ATPase phospholipid transporting 10D (putative)
704458
Mouse
MGI:2450125
231287
Rat
RGD:1588541
360932
Dog
ATPase phospholipid transporting 10D (putative)
482134
Horse
ATPase phospholipid transporting 10D (putative)
100061624
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ATPase phospholipid transporting 10D (putative)
Mouse
Rat
Dog
ATPase phospholipid transporting 10D (putative)
Horse
ATPase phospholipid transporting 10D (putative)
Publication Statistics
PubMed Score 4.57
PubMed score by year
PubTator Score 2.70
PubTator score by year