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Tdark
ARHGAP23
Rho GTPase-activating protein 23

Protein Summary
Description
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. The RHO (see ARHA; MIM 165390) family of small GTPases are involved in signal transduction through transmembrane receptors, and they are inactive in the GDP-bound form and active in the GTP-bound form. GTPase-activating proteins, such as ARHGAP23, inactivate RHO family proteins by stimulating their hydrolysis of GTP (Katoh and Katoh, 2004 [PubMed 15254754]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000610551
  • ENSP00000479208
  • ENSG00000273780
  • ENST00000620417
  • ENSP00000482992
  • ENSG00000275832
  • ENST00000622683
  • ENSP00000481862
  • ENST00000631799
  • ENSP00000488428

Symbol
  • KIAA1501
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
transcription factor
0.67
tissue sample
0.66
cellular component
0.59
cell line
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.23   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 29   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.23   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 29   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
2
2
67.7
red blood cell distribution width
2
2
2
67.7
monocyte count
1
1
1
58.1
monocyte count
1
1
1
58.1
leukocyte count
1
1
1
30.2
Items per page:
1 – 5 of 14
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
67.7
red blood cell distribution width
2
67.7
monocyte count
1
58.1
monocyte count
1
58.1
leukocyte count
1
30.2
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:3697726
58996
Rat
RGD:1309742
303501
Dog
Rho GTPase activating protein 23
VGNC:38052
491038
Pig
Rho GTPase activating protein 23
100514368
Opossum
Rho GTPase activating protein 23
100018785
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
Rho GTPase activating protein 23
Pig
Rho GTPase activating protein 23
Opossum
Rho GTPase activating protein 23
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9P227-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Rho GTPase cycle (R-HSA-194840)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
Rho GTPase cycle
Signal Transduction
Signaling by Rho GTPases
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (56)
1 – 10 of 56
SAPCD1
Tdark
Novelty: 0.90892824
p_int: 0.99995064
p_ni: 0.00004936
Score: 0.485
Data Source: BioPlex,STRINGDB
RHOA
Tbio
Family: Enzyme
Novelty: 0.00022204
Score: 0.944
Data Source: STRINGDB
RHOU
Tbio
Family: Enzyme
Novelty: 0.01456329
Score: 0.931
Data Source: STRINGDB
CDC42
Tchem
Family: Enzyme
Novelty: 0.00032619
Score: 0.93
Data Source: STRINGDB
RHOBTB2
Tbio
Novelty: 0.00734789
Score: 0.916
Data Source: STRINGDB
RHOG
Tbio
Family: Enzyme
Novelty: 0.00412327
Score: 0.915
Data Source: STRINGDB
RHOBTB1
Tbio
Novelty: 0.02152609
Score: 0.915
Data Source: STRINGDB
RAC3
Tbio
Family: Enzyme
Novelty: 0.02125361
Score: 0.915
Data Source: STRINGDB
RHOB
Tbio
Family: Enzyme
Novelty: 0.0019205
Score: 0.914
Data Source: STRINGDB
RHOD
Tbio
Family: Enzyme
Novelty: 0.0029764
Score: 0.914
Data Source: STRINGDB
Publication Statistics
PubMed Score  2.23

PubMed score by year
PubTator Score  1.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer