Tdark ARHGAP23 Rho GTPase-activating protein 23

Protein Summary

Description

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. The RHO (see ARHA; MIM 165390) family of small GTPases are involved in signal transduction through transmembrane receptors, and they are inactive in the GDP-bound form and active in the GTP-bound form. GTPase-activating proteins, such as ARHGAP23, inactivate RHO family proteins by stimulating their hydrolysis of GTP (Katoh and Katoh, 2004 [PubMed 15254754]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q9P227

Gene Name

• ARHGAP23

Ensembl ID

• ENST00000610551
• ENSP00000479208
• ENSG00000273780
• ENST00000620417
• ENSP00000482992
• ENSG00000275832
• ENST00000622683
• ENSP00000481862
• ENST00000631799
• ENSP00000488428

Symbol

• KIAA1501

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.73
transcription factor	0.67
tissue sample	0.66
cellular component	0.59
cell line	0.57

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.14   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 29   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.14   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 29   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0