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Tbio
DNAH2
Dynein heavy chain 2, axonemal

Protein Summary
Description
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. The axonemal dyneins, found in cilia and flagella, are components of the outer and inner dynein arms attached to the peripheral microtubule doublets. DNAH2 is an axonemal inner arm dynein heavy chain (Chapelin et al., 1997 [PubMed 9256245]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389173
  • ENSP00000373825
  • ENSG00000183914
  • ENST00000570791
  • ENSP00000460245
  • ENST00000572933
  • ENSP00000458355

Symbol
  • DNAHC2
  • DNHD3
  • KIAA1503
  • DNHD3
  • DNAHC2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
molecular function
0.93
interacting protein
0.72
transcription factor
0.62
tissue sample
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.36   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 64   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.36   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
3
1
3
85.9
1
1
0
1.8
81.7
hemoglobin measurement
3
2
3
81.2
red blood cell density measurement
1
1
1
78.4
appendicular lean mass
1
1
1
75.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
3
85.9
0
1.8
81.7
hemoglobin measurement
3
81.2
red blood cell density measurement
1
78.4
appendicular lean mass
1
75.1
Gene Ontology Terms (12)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (90)
1 – 10 of 90
DYNC1LI1
Tbio
Novelty: 0.02164556
Score: 0.934
Data Source: STRINGDB
DYNLT3
Tbio
Novelty: 0.10969629
Score: 0.934
Data Source: STRINGDB
DNAH1
Tbio
Novelty: 0.0369386
Score: 0.914
Data Source: STRINGDB
DNAH8
Tbio
Novelty: 0.10883442
Score: 0.913
Data Source: STRINGDB
DNAH7
Tbio
Novelty: 0.13519686
Score: 0.913
Data Source: STRINGDB
DNAH3
Tdark
Novelty: 0.0628368
Score: 0.912
Data Source: STRINGDB
DNAH17
Tdark
Novelty: 0.14878692
Score: 0.911
Data Source: STRINGDB
TPR
Tbio
Novelty: 0.00462503
Score: 0.902
Data Source: STRINGDB
SNX4
Tbio
Novelty: 0.05441145
Score: 0.9
Data Source: STRINGDB
DNAL4
Tbio
Novelty: 0.15546154
Score: 0.859
Data Source: STRINGDB
Publication Statistics
PubMed Score  8.36

PubMed score by year
PubTator Score  2.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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