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Tbio
CCDC88C
Protein Daple

Protein Summary
Description
Negative regulator of the canonical Wnt signaling pathway, acting downstream of DVL to inhibit CTNNB1/Beta-catenin stabilization (By similarity). May also activate the JNK signaling pathway (PubMed:25062847). This gene encodes a ubiquitously expressed coiled-coil domain-containing protein that interacts with the dishevelled protein and is a negative regulator of the Wnt signalling pathway. The protein encoded by this gene has a PDZ-domain binding motif in its C-terminus with which it interacts with the dishevelled protein. Dishevelled is a scaffold protein involved in the regulation of the Wnt signaling pathway. The Wnt signaling pathway plays an important role in embryonic development, tissue maintenance, and cancer progression. Mutations in this gene cause autosomal recessive, primary non-syndromic congenital hydrocephalus; a condition characterized by excessive accumulation of cerebrospinal fluid in the ventricles of the brain. [provided by RefSeq, Jan 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389857
  • ENSP00000374507
  • ENSG00000015133

Symbol
  • DAPLE
  • KIAA1509
  • HYC1
  • DAPLE
  • HKRP2
  • SCA40
  • KIAA1509
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
transcription factor binding site profile
0.84
trait
0.75
transcription factor
0.7
cell type or tissue
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.55   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 11   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.55   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 11   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (37)
MCM7
Tbio
Novelty:  0.0017984
p_int:  0.999998299
p_ni:  0.000001701
p_wrong:  1e-9
Score:  0.262
Data Source:  BioPlex,STRINGDB
SYCE1
Tbio
Novelty:  0.05038876
p_int:  0.999813979
p_ni:  0.000186013
p_wrong:  8e-9
Data Source:  BioPlex
WDFY1
Tbio
Novelty:  0.13382544
p_int:  0.999532011
p_ni:  0.000467989
Score:  0.205
Data Source:  BioPlex,STRINGDB
RNASE7
Tbio
Family:  Enzyme
Novelty:  0.01866347
p_int:  0.97590748
p_ni:  0.02409077
p_wrong:  0.00000175
Score:  0.189
Data Source:  BioPlex,STRINGDB
ALDH1L1
Tbio
Family:  Enzyme
Novelty:  0.01123871
p_int:  0.929212686
p_ni:  0.070787314
Score:  0.549
Data Source:  BioPlex,STRINGDB
DVL1
Tchem
Novelty:  0.00356876
Score:  0.977
Data Source:  STRINGDB
DVL2
Tbio
Novelty:  0.00833084
Score:  0.947
Data Source:  Reactome,STRINGDB
DVL3
Tbio
Novelty:  0.01606014
Score:  0.918
Data Source:  Reactome,STRINGDB
GNAI3
Tbio
Novelty:  0.03484857
Score:  0.828
Data Source:  STRINGDB
CLVS1
Tbio
Novelty:  0.275056
Score:  0.659
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Negative regulation of TCF-dependent signaling by DVL-interacting proteins (R-HSA-5368598)

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Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Negative regulation of TCF-dependent signaling by DVL-interacting proteins
Reactome
Signal Transduction
Reactome
Signaling by WNT
Reactome
TCF dependent signaling in response to WNT
Name
Explore in Pharos
Explore in Source
Negative regulation of TCF-dependent signaling by DVL-interacting proteins
Signal Transduction
Signaling by WNT
TCF dependent signaling in response to WNT
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
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Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
2
1
1.1
83.8
1
1
1
71.7
1
1
1
71.7
type 2 diabetes mellitus
3
1
2
1
61.4
brain measurement
1
1
0
8.7
60
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
83.8
1
71.7
1
71.7
type 2 diabetes mellitus
2
1
61.4
brain measurement
0
8.7
60
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coiled-coil domain containing 88C
VGNC:3454
453108
Mouse
MGI:1915589
68339
Rat
RGD:1307429
362770
Dog
coiled-coil domain containing 88C
VGNC:38869
480418
Horse
coiled-coil domain containing 88C
VGNC:16186
100063079
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coiled-coil domain containing 88C
Mouse
Rat
Dog
coiled-coil domain containing 88C
Horse
coiled-coil domain containing 88C
Publication Statistics
PubMed Score 33.55
PubMed score by year
PubTator Score 20.04
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title