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Tbio
PLCE1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1

Protein Classes
Protein Summary
Description
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation. This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, this enzyme has ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371375
  • ENSP00000360426
  • ENSG00000138193
  • ENST00000371380
  • ENSP00000360431
  • ENST00000371385
  • ENSP00000360438

Symbol
  • KIAA1516
  • PLCE
  • PPLC
  • PLCE
  • PPLC
  • NPHS3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
trait
1
biological process
0.91
metabolite
0.89
disease
0.78


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.49   (req: < 5)
Gene RIFs: 106   (req: <= 3)
Antibodies: 42   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.49   (req: >= 5)
Gene RIFs: 106   (req: > 3)
Antibodies: 42   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (39)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
9
18
99.1
parental genotype effect measurement
1
3
3
88.9
birth weight
3
3
6
88.9
2
3
0
1.4
88.2
platelet crit
2
3
3
87.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
18
99.1
parental genotype effect measurement
3
88.9
birth weight
6
88.9
0
1.4
88.2
platelet crit
3
87.5
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1921305
74055
Rat
RGD:69424
114633
Dog
phospholipase C epsilon 1
VGNC:44650
486808
Horse
phospholipase C epsilon 1
VGNC:51637
100061676
Cow
phospholipase C epsilon 1
VGNC:32987
519037
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
phospholipase C epsilon 1
Horse
phospholipase C epsilon 1
Cow
phospholipase C epsilon 1
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9P212-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (32)
Inositol phosphate metabolism (R-HSA-1483249)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Inositol phosphate metabolism
Reactome
Metabolism
Reactome
Synthesis of IP3 and IP4 in the cytosol
Name
Explore in Pharos
Explore in Source
Inositol phosphate metabolism
Metabolism
Synthesis of IP3 and IP4 in the cytosol
Gene Ontology Terms (28)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (144)
1 – 10 of 144
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
Score:  0.952
Data Source:  STRINGDB
RAP2B
Tbio
Family:  Enzyme
Novelty:  0.00347321
Score:  0.936
Data Source:  STRINGDB
PIP5K1A
Tbio
Family:  Kinase
Novelty:  0.05039085
Score:  0.936
Data Source:  STRINGDB
PIP5K1B
Tbio
Family:  Kinase
Novelty:  0.05013433
Score:  0.934
Data Source:  STRINGDB
PIP5KL1
Tbio
Family:  Enzyme
Novelty:  0.15208771
Score:  0.932
Data Source:  STRINGDB
PIP5K1C
Tchem
Family:  Kinase
Novelty:  0.0323077
Score:  0.93
Data Source:  STRINGDB
IPMK
Tbio
Family:  Kinase
Novelty:  0.01837813
Score:  0.923
Data Source:  STRINGDB
ITPKA
Tchem
Family:  Kinase
Novelty:  0.02901348
Score:  0.921
Data Source:  STRINGDB
RRAS
Tbio
Family:  Enzyme
Novelty:  0.00786502
Score:  0.918
Data Source:  STRINGDB
ITPKB
Tchem
Family:  Kinase
Novelty:  0.02397335
Score:  0.914
Data Source:  STRINGDB
Publication Statistics
PubMed Score  147.49

PubMed score by year
PubTator Score  88.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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