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Tclin
HCN3
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3

Protein Summary
Description
Hyperpolarization-activated potassium channel. May also facilitate the permeation of sodium ions. This gene encodes a multi-pass membrane protein that functions as a voltage gated cation channel. The encoded protein is a member of a family of closely related cyclic adenosine monophosphate-binding channel proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368358
  • ENSP00000357342
  • ENSG00000143630
  • ENST00000575670
  • ENSP00000458364
  • ENSG00000263324

Symbol
  • KIAA1535
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
virus perturbation
0.99
protein domain
0.85
cell line
0.61
transcription factor binding site profile
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.77   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 274   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.77   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 274   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (46)
KCTD3
Tdark
Novelty:  0.33599775
Score:  0.779
Data Source:  STRINGDB
PEX5L
Tbio
Novelty:  0.01922466
Score:  0.775
Data Source:  STRINGDB
TPCN1
Tchem
Family:  IC
Novelty:  0.003844
Score:  0.647
Data Source:  STRINGDB
SCN5A
Tclin
Family:  IC
Novelty:  0.00050944
Score:  0.631
Data Source:  STRINGDB
NKX2-5
Tbio
Family:  TF
Novelty:  0.00125993
Score:  0.628
Data Source:  STRINGDB
TBX3
Tbio
Family:  TF
Novelty:  0.00515507
Score:  0.625
Data Source:  STRINGDB
KCNE2
Tbio
Family:  IC
Novelty:  0.0073267
Score:  0.612
Data Source:  STRINGDB
CCDC151
Tbio
Novelty:  0.15952702
Score:  0.571
Data Source:  STRINGDB
KCNQ2
Tclin
Family:  IC
Novelty:  0.00209684
Score:  0.561
Data Source:  STRINGDB
KCNJ2
Tchem
Family:  IC
Novelty:  0.00290395
Score:  0.555
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
HCN channels (R-HSA-1296061)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
HCN channels
Reactome
Neuronal System
Reactome
Potassium Channels
Name
Explore in Pharos
Explore in Source
HCN channels
Neuronal System
Potassium Channels
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (74)
Items per page:
1 – 5 of 74
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
6
3
7
96.1
urate measurement
6
3
7
96.1
serum urea measurement
2
2
2
94.2
serum urea measurement
2
2
2
94.2
reticulocyte measurement
3
2
4
93.8
Items per page:
1 – 5 of 74
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
7
96.1
urate measurement
7
96.1
serum urea measurement
2
94.2
serum urea measurement
2
94.2
reticulocyte measurement
4
93.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hyperpolarization activated cyclic nucleotide gated potassium channel 3
VGNC:10660
457365
Mouse
MGI:1298211
15168
Rat
RGD:620691
114245
Dog
hyperpolarization activated cyclic nucleotide gated potassium channel 3
VGNC:41621
490426
Horse
hyperpolarization activated cyclic nucleotide gated potassium channel 3
VGNC:18712
100063574
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hyperpolarization activated cyclic nucleotide gated potassium channel 3
Mouse
Rat
Dog
hyperpolarization activated cyclic nucleotide gated potassium channel 3
Horse
hyperpolarization activated cyclic nucleotide gated potassium channel 3
Publication Statistics
PubMed Score 59.77
PubMed score by year
PubTator Score 19.70
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title