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Tbio
ZBTB4
Zinc finger and BTB domain-containing protein 4

Protein Summary
Description
Transcriptional repressor with bimodal DNA-binding specificity. Represses transcription in a methyl-CpG-dependent manner. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA (PubMed:16354688). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311403
  • ENSP00000307858
  • ENSG00000174282
  • ENST00000380599
  • ENSP00000369973
  • ENST00000639670
  • ENSP00000492232
  • ENSG00000283868
  • ENST00000639962
  • ENSP00000492616

Symbol
  • KIAA1538
  • ZNF903
  • KAISO-L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
protein domain
0.85
transcription factor binding site profile
0.84
microRNA
0.77
transcription factor perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.37   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.37   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
1
3
83.2
body height
2
2
2
83.2
heel bone mineral density
1
1
1
73.8
mathematical ability
1
1
1
60
self reported educational attainment
1
1
1
52
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
83.2
body height
2
83.2
heel bone mineral density
1
73.8
mathematical ability
1
60
self reported educational attainment
1
52
Gene Ontology Terms (20)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Protein-Protein Interactions (34)
1 – 10 of 34
PRDM5
Tbio
Family: TF; Epigenetic
Novelty: 0.01689997
p_int: 0.996203947
p_ni: 6.51e-7
p_wrong: 0.003795402
Score: 0.234
Data Source: BioPlex,STRINGDB
SP1
Tbio
Family: TF
Novelty: 0.0007915
Score: 0.658
Data Source: STRINGDB
SIN3B
Tbio
Novelty: 0.04097105
Score: 0.611
Data Source: STRINGDB
UHRF2
Tbio
Family: Epigenetic
Novelty: 0.02205863
Score: 0.606
Data Source: STRINGDB
SIN3A
Tbio
Novelty: 0.00747207
Score: 0.606
Data Source: STRINGDB
EZH2
Tclin
Family: Epigenetic
Novelty: 0.00052816
Score: 0.586
Data Source: STRINGDB
MGMT
Tchem
Family: Enzyme
Novelty: 0.00050216
Score: 0.575
Data Source: STRINGDB
RAPSN
Tbio
Novelty: 0.00565077
Score: 0.55
Data Source: STRINGDB
CTNND2
Tbio
Novelty: 0.01178779
Score: 0.547
Data Source: STRINGDB
HES7
Tbio
Family: TF
Novelty: 0.02014919
Score: 0.546
Data Source: STRINGDB
Publication Statistics
PubMed Score  15.37

PubMed score by year
PubTator Score  7.18

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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