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Tchem
PIM2
Serine/threonine-protein kinase pim-2

Protein Summary
Description
Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals via positive regulation of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376509
  • ENSP00000365692
  • ENSG00000102096
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
disease perturbation
0.79
biological process
0.77
histone modification site profile
0.77
gene perturbation
0.75


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 387.16   (req: < 5)
Gene RIFs: 48   (req: <= 3)
Antibodies: 417   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 387.16   (req: >= 5)
Gene RIFs: 48   (req: > 3)
Antibodies: 417   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1203
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
ruboxistaurin
chemical structure image
Active Ligands (1203)
1 – 10 of 1203
CHEMBL388978
chemical structure image
CHEMBL1952329,CHEMBL1952141
chemical structure image
CHEMBL1915438
chemical structure image
CHEMBL1952142
chemical structure image
CHEMBL3393706
chemical structure image
CHEMBL3942186
chemical structure image
CHEMBL1915448
chemical structure image
CHEMBL3942619
chemical structure image
CHEMBL3963605
chemical structure image
CHEMBL3895998
chemical structure image
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:97587
18715
Rat
RGD:1560759
317366
Dog
Pim-2 proto-oncogene, serine/threonine kinase
VGNC:44565
442959
Cow
Pim-2 proto-oncogene, serine/threonine kinase
VGNC:32900
508424
Opossum
Pim-2 proto-oncogene, serine/threonine kinase
100019195
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
Pim-2 proto-oncogene, serine/threonine kinase
Cow
Pim-2 proto-oncogene, serine/threonine kinase
Opossum
Pim-2 proto-oncogene, serine/threonine kinase
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9P1W9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (18)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (44)
1 – 10 of 44
PIM1
Tchem
Family: Kinase
Novelty: 0.0049837
Score: 0.819
Data Source: STRINGDB
MYC
Tbio
Family: TF
Novelty: 0.00005734
Score: 0.714
Data Source: STRINGDB
STAT5B
Tchem
Family: TF
Novelty: 0.00074178
Score: 0.705
Data Source: STRINGDB
EIF4EBP1
Tbio
Novelty: 0.00098313
Score: 0.702
Data Source: STRINGDB
STAT5A
Tchem
Family: TF
Novelty: 0.00074026
Score: 0.693
Data Source: STRINGDB
FOXP3
Tbio
Family: TF
Novelty: 0.00017205
Score: 0.634
Data Source: STRINGDB
SOCS1
Tbio
Novelty: 0.00131368
Score: 0.625
Data Source: STRINGDB
TNFSF13B
Tclin
Novelty: 0.00069885
Score: 0.625
Data Source: STRINGDB
SOCS3
Tbio
Novelty: 0.00106095
Score: 0.614
Data Source: STRINGDB
CDKN1A
Tbio
Family: Enzyme
Novelty: 0.00033009
Score: 0.607
Data Source: STRINGDB
Publication Statistics
PubMed Score  387.16

PubMed score by year
PubTator Score  140.13

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer