Tchem PIM2 Serine/threonine-protein kinase pim-2

Protein Summary

Description

Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappa-B kinase/NF-kappa-B cascade; this process requires phosphorylation of MAP3K8/COT. Promotes growth factor-independent proliferation by phosphorylation of cell cycle factors such as CDKN1A and CDKN1B. Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate. This gene encodes a protooncogene that acts as a serine/threonine protein kinase. Studies determined the encoded protein functions to prevent apoptosis and to promote cell survival.[provided by RefSeq, Nov 2009]

Uniprot Accession IDs

• Q9P1W9
• A8K4G6
• Q99739

Gene Name

• PIM2

Ensembl ID

• ENST00000376509
• ENSP00000365692
• ENSG00000102096

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.91
disease perturbation	0.79
biological process	0.77
histone modification site profile	0.77
gene perturbation	0.75

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Serine/threonine Protein Kinase Receptor / Serine/threonine-protein Kinase Pim-2

Protein / Receptor / Protein Kinase Receptor / Serine/threonine Protein Kinase Receptor / Serine/threonine-protein Kinase Pim-2

DTO Classes

Protein / Kinase / Protein Kinase / Camk Group / Pim Family / Serine/threonine-protein Kinase Pim-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 494.38   (req: < 5)

Gene RIFs: 61   (req: <= 3)

Antibodies: 417   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 494.38   (req: >= 5)

Gene RIFs: 61   (req: > 3)

Antibodies: 417   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1334

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1