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Tchem
PIM2
Serine/threonine-protein kinase pim-2

Protein Summary
Description
Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals via positive regulation of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376509
  • ENSP00000365692
  • ENSG00000102096
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
disease perturbation
0.79
biological process
0.77
histone modification site profile
0.77
gene perturbation
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 403.82   (req: < 5)
Gene RIFs: 48   (req: <= 3)
Antibodies: 417   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 403.82   (req: >= 5)
Gene RIFs: 48   (req: > 3)
Antibodies: 417   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1321
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (44)
PIM1
Tchem
Family:  Kinase
Novelty:  0.0049837
Score:  0.819
Data Source:  STRINGDB
MYC
Tchem
Family:  TF
Novelty:  0.00005734
Score:  0.714
Data Source:  STRINGDB
STAT5B
Tchem
Family:  TF
Novelty:  0.00074178
Score:  0.705
Data Source:  STRINGDB
EIF4EBP1
Tbio
Novelty:  0.00098313
Score:  0.702
Data Source:  STRINGDB
STAT5A
Tchem
Family:  TF
Novelty:  0.00074026
Score:  0.693
Data Source:  STRINGDB
FOXP3
Tbio
Family:  TF
Novelty:  0.00017205
Score:  0.634
Data Source:  STRINGDB
SOCS1
Tbio
Novelty:  0.00131368
Score:  0.625
Data Source:  STRINGDB
TNFSF13B
Tclin
Novelty:  0.00069885
Score:  0.625
Data Source:  STRINGDB
SOCS3
Tbio
Novelty:  0.00106095
Score:  0.614
Data Source:  STRINGDB
CDKN1A
Tchem
Family:  Enzyme
Novelty:  0.00033009
Score:  0.607
Data Source:  STRINGDB
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
1
1
59.8
eosinophil percentage of leukocytes
1
1
1
56.2
1
1
0
1.1
2.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
59.8
eosinophil percentage of leukocytes
1
56.2
0
1.1
2.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:97587
18715
Rat
RGD:1560759
317366
Dog
Pim-2 proto-oncogene, serine/threonine kinase
VGNC:44565
442959
Cow
Pim-2 proto-oncogene, serine/threonine kinase
VGNC:32900
508424
Opossum
Pim-2 proto-oncogene, serine/threonine kinase
100019195
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
Pim-2 proto-oncogene, serine/threonine kinase
Cow
Pim-2 proto-oncogene, serine/threonine kinase
Opossum
Pim-2 proto-oncogene, serine/threonine kinase
Publication Statistics
PubMed Score 403.82
PubMed score by year
PubTator Score 140.13
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title