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Tchem
PIM2
Serine/threonine-protein kinase pim-2

Protein Summary
Description
Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals via positive regulation of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376509
  • ENSP00000365692
  • ENSG00000102096
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
disease perturbation
0.79
biological process
0.77
histone modification site profile
0.77
gene perturbation
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 387.16   (req: < 5)
Gene RIFs: 48   (req: <= 3)
Antibodies: 417   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 387.16   (req: >= 5)
Gene RIFs: 48   (req: > 3)
Antibodies: 417   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1203
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
ruboxistaurin
chemical structure image
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (18)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (44)
1 – 10 of 44
PIM1
Tchem
Family: Kinase
Novelty: 0.0049837
Score: 0.819
Data Source: STRINGDB
MYC
Tbio
Family: TF
Novelty: 0.00005734
Score: 0.714
Data Source: STRINGDB
STAT5B
Tchem
Family: TF
Novelty: 0.00074178
Score: 0.705
Data Source: STRINGDB
EIF4EBP1
Tbio
Novelty: 0.00098313
Score: 0.702
Data Source: STRINGDB
STAT5A
Tchem
Family: TF
Novelty: 0.00074026
Score: 0.693
Data Source: STRINGDB
FOXP3
Tbio
Family: TF
Novelty: 0.00017205
Score: 0.634
Data Source: STRINGDB
SOCS1
Tbio
Novelty: 0.00131368
Score: 0.625
Data Source: STRINGDB
TNFSF13B
Tclin
Novelty: 0.00069885
Score: 0.625
Data Source: STRINGDB
SOCS3
Tbio
Novelty: 0.00106095
Score: 0.614
Data Source: STRINGDB
CDKN1A
Tbio
Family: Enzyme
Novelty: 0.00033009
Score: 0.607
Data Source: STRINGDB
Publication Statistics
PubMed Score  387.16

PubMed score by year
PubTator Score  140.13

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer