SIRPG
Signal-regulatory protein gamma
Protein Summary
Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation. The protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
- ENST00000216927
- ENSP00000216927
- ENSG00000089012
- ENST00000303415
- ENSP00000305529
- ENST00000344103
- ENSP00000342759
- ENST00000381580
- ENSP00000370992
- ENST00000381583
- ENSP00000370995
- SIRPB2
- CD172g
- SIRPB2
- SIRP-B2
- bA77C3.1
- SIRPgamma
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.73 | ||
phenotype | 0.57 | ||
tissue sample | 0.5 | ||
biological process | 0.44 | ||
tissue | 0.44 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10.79 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 293 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10.79 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 293 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0