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Tbio
SIRPG
Signal-regulatory protein gamma

Protein Summary
Description
Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation. The protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216927
  • ENSP00000216927
  • ENSG00000089012
  • ENST00000303415
  • ENSP00000305529
  • ENST00000344103
  • ENSP00000342759
  • ENST00000381580
  • ENSP00000370992
  • ENST00000381583
  • ENSP00000370995

Symbol
  • SIRPB2
  • CD172g
  • SIRPB2
  • SIRP-B2
  • bA77C3.1
  • SIRPgamma
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
phenotype
0.57
tissue sample
0.5
biological process
0.44
tissue
0.44


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.42   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 293   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.42   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 293   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.1
76.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
76.7
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
Cell surface interactions at the vascular wall (R-HSA-202733)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Cell-Cell communication
Reactome
Hemostasis
Reactome
Signal regulatory protein family interactions
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Cell-Cell communication
Hemostasis
Signal regulatory protein family interactions
Gene Ontology Terms (12)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (21)
1 – 10 of 21
SIRPA
Tbio
Family: Enzyme
Novelty: 0.0021102
p_int: 1
Score: 0.937
Data Source: BioPlex,STRINGDB
LTF
Tbio
Novelty: 0.00114254
p_int: 0.914129409
p_ni: 0.085870591
Score: 0.238
Data Source: BioPlex,STRINGDB
CD47
Tchem
Novelty: 0.00129086
Score: 0.996
Data Source: Reactome,STRINGDB
TYROBP
Tbio
Family: Enzyme
Novelty: 0.00410031
Score: 0.93
Data Source: STRINGDB
TREM2
Tbio
Novelty: 0.00228007
Score: 0.809
Data Source: STRINGDB
SYK
Tclin
Family: Kinase
Novelty: 0.00058994
Score: 0.809
Data Source: STRINGDB
CD2
Tclin
Novelty: 0.00037283
Score: 0.556
Data Source: STRINGDB
UBASH3A
Tbio
Novelty: 0.01418497
Score: 0.555
Data Source: STRINGDB
ATP10D
Tdark
Family: Transporter
Novelty: 0.21272192
Score: 0.544
Data Source: STRINGDB
TMEM86B
Tbio
Family: Enzyme
Novelty: 0.26982157
Score: 0.532
Data Source: STRINGDB
Publication Statistics
PubMed Score  7.42

PubMed score by year
PubTator Score  6.05

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer