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Tbio
CLEC1B
C-type lectin domain family 1 member B

Protein Summary
Description
C-type lectin-like receptor that functions as a platelet receptor for the lymphatic endothelial marker, PDPN (PubMed:18215137). After ligand activation, signals via sequential activation of SRC and SYK tyrosine kinases leading to activation of PLCG2 (PubMed:18955485). (Microbial infection) Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (SYK) and initiation of downstream tyrosine phosphorylation events and activation of PLCG2 (PubMed:16174766, PubMed:18955485). (Microbial infection) Acts as an attachment factor for Human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets (PubMed:16940507). Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and eit ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298527
  • ENSP00000298527
  • ENSG00000165682
  • ENST00000348658
  • ENSP00000327169
  • ENST00000428126
  • ENSP00000406338

Symbol
  • CLEC2
  • CLEC2
  • CLEC2B
  • PRO1384
  • QDED721
  • 1810061I13Rik
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.61
phenotype
0.59
tissue
0.55
cell type or tissue
0.54
trait
0.46


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.83   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 312   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.83   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 312   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C-type lectin domain family 1 member B
VGNC:8372
465283
Macaque
C-type lectin domain family 1 member B
717404
Mouse
MGI:1913287
56760
Rat
RGD:1563517
500336
Dog
C-type lectin domain family 1 member B
VGNC:49802
611394
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C-type lectin domain family 1 member B
Macaque
C-type lectin domain family 1 member B
Mouse
Rat
Dog
C-type lectin domain family 1 member B
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9P126-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
GPVI-mediated activation cascade (R-HSA-114604)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
GPVI-mediated activation cascade
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Name
Explore in Pharos
Explore in Source
GPVI-mediated activation cascade
Hemostasis
Platelet activation, signaling and aggregation
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (40)
1 – 10 of 40
PDPN
Tbio
Novelty: 0.00024118
Score: 0.993
Data Source: Reactome,STRINGDB
SYK
Tclin
Family: Kinase
Novelty: 0.00058994
Score: 0.983
Data Source: Reactome,STRINGDB
LCP2
Tbio
Novelty: 0.00512968
Score: 0.963
Data Source: STRINGDB
PLCG2
Tchem
Family: Enzyme
Novelty: 0.00294726
Score: 0.958
Data Source: STRINGDB
MPIG6B
Tbio
Novelty: 0.04808462
Score: 0.945
Data Source: STRINGDB
PTPN11
Tchem
Family: Enzyme
Novelty: 0.00073124
Score: 0.921
Data Source: STRINGDB
PTPN6
Tchem
Family: Enzyme
Novelty: 0.00535749
Score: 0.909
Data Source: STRINGDB
GP6
Tbio
Novelty: 0.0010722
Score: 0.767
Data Source: STRINGDB
KLRC4
Tbio
Novelty: 0.16922525
Score: 0.635
Data Source: STRINGDB
CLEC2D
Tbio
Novelty: 0.02501194
Score: 0.63
Data Source: STRINGDB
Publication Statistics
PubMed Score  137.83

PubMed score by year
PubTator Score  79.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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