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Tbio
NTM
Neurotrimin

Protein Summary
Description
Neural cell adhesion molecule. This gene encodes a member of the IgLON (LAMP, OBCAM, Ntm) family of immunoglobulin (Ig) domain-containing glycosylphosphatidylinositol (GPI)-anchored cell adhesion molecules. The encoded protein may promote neurite outgrowth and adhesion via a homophilic mechanism. This gene is closely linked to a related family member, opioid binding protein/cell adhesion molecule-like (OPCML), on chromosome 11. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374784
  • ENSP00000363916
  • ENSG00000182667
  • ENST00000374786
  • ENSP00000363918
  • ENST00000374791
  • ENSP00000363923
  • ENST00000425719
  • ENSP00000396722

Symbol
  • IGLON2
  • NT
  • HNT
  • NTRI
  • CEPU-1
  • IGLON2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
virus perturbation
0.83
phenotype
0.81
gene perturbation
0.8
microRNA
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.73   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 178   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.73   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
3
3
96.2
smoking status measurement
2
2
4
91.5
body mass index
1
2
2
82.8
lifestyle measurement
2
2
2
82.2
refractive error measurement
2
2
1
6.9
81.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
96.2
smoking status measurement
4
91.5
body mass index
2
82.8
lifestyle measurement
2
82.2
refractive error measurement
1
6.9
81.4
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neurotrimin
VGNC:50535
451673
Macaque
neurotrimin
693345
Mouse
MGI:2446259
235106
Rat
RGD:620958
50864
Dog
neurotrimin
VGNC:44005
489274
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neurotrimin
Macaque
neurotrimin
Mouse
Rat
Dog
neurotrimin
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9P121-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Gene Ontology Terms (5)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (96)
1 – 10 of 96
OPCML
Tbio
Novelty: 0.01569352
p_int: 0.999999999
p_ni: 1e-9
Score: 0.987
Data Source: BioPlex,STRINGDB
HAX1
Tbio
Novelty: 0.00749205
p_int: 0.999086225
p_ni: 0.000913767
p_wrong: 8e-9
Data Source: BioPlex
FBXO2
Tbio
Novelty: 0.01578361
p_int: 0.995153059
p_ni: 0.004846918
p_wrong: 2.3e-8
Score: 0.668
Data Source: BioPlex,STRINGDB
NUFIP1
Tbio
Novelty: 0.11726869
p_int: 0.992523915
p_ni: 0.007474024
p_wrong: 0.00000206
Data Source: BioPlex
DGUOK
Tbio
Family: Kinase
Novelty: 0.00897987
p_int: 0.992345656
p_ni: 0.007653542
p_wrong: 8.02e-7
Data Source: BioPlex
CALR
Tbio
Novelty: 0.0004479
p_int: 0.906818508
p_ni: 0.093181492
Score: 0.241
Data Source: BioPlex,STRINGDB
NEGR1
Tbio
Novelty: 0.0088917
Score: 0.954
Data Source: STRINGDB
THY1
Tbio
Novelty: 0.00032846
Score: 0.939
Data Source: STRINGDB
LSAMP
Tbio
Novelty: 0.01237032
Score: 0.931
Data Source: STRINGDB
LYPD1
Tbio
Novelty: 0.10740408
Score: 0.927
Data Source: STRINGDB
Publication Statistics
PubMed Score  57.73

PubMed score by year
PubTator Score  99.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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