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Tbio
GMIP
GEM-interacting protein

Protein Summary
Description
Stimulates, in vitro and in vivo, the GTPase activity of RhoA. This gene encodes a member of the ARHGAP family of Rho/Rac/Cdc42-like GTPase activating proteins. The encoded protein interacts with the Ras-related protein Gem through its N-terminal domain. Separately, it interacts with RhoA through a RhoGAP domain, and stimulates RhoA-dependent GTPase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000203556
  • ENSP00000203556
  • ENSG00000089639
  • ENST00000587238
  • ENSP00000467054

Symbol
  • ARHGAP46
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.86
metabolite
0.82
histone modification site profile
0.75
co-expressed gene
0.69
small molecule perturbation
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.83   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 70   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.83   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 70   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (36)
CTAG1A
Tbio
Novelty:  0.00345306
p_int:  0.999994965
p_ni:  0.000005035
Data Source:  BioPlex
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
Score:  0.965
Data Source:  STRINGDB
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.934
Data Source:  STRINGDB
RAC2
Tbio
Family:  Enzyme
Novelty:  0.00116234
Score:  0.932
Data Source:  STRINGDB
RHOU
Tbio
Family:  Enzyme
Novelty:  0.01456329
Score:  0.929
Data Source:  STRINGDB
RHOG
Tbio
Family:  Enzyme
Novelty:  0.00412327
Score:  0.921
Data Source:  STRINGDB
RHOH
Tbio
Family:  Enzyme
Novelty:  0.00882842
Score:  0.914
Data Source:  STRINGDB
RAC1
Tbio
Family:  Enzyme
Novelty:  0.00365325
Score:  0.913
Data Source:  STRINGDB
RAC3
Tbio
Family:  Enzyme
Novelty:  0.02125361
Score:  0.912
Data Source:  STRINGDB
RHOF
Tbio
Family:  Enzyme
Novelty:  0.01795771
Score:  0.912
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Rho GTPase cycle (R-HSA-194840)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
Rho GTPase cycle
Signal Transduction
Signaling by Rho GTPases
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (49)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
11
8
15
6.9
99.6
low density lipoprotein cholesterol measurement
4
5
5
3.3
99.4
total cholesterol measurement
4
4
7
98.8
bilirubin measurement
2
3
4
90
apolipoprotein B measurement
1
3
3
87
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
15
6.9
99.6
low density lipoprotein cholesterol measurement
5
3.3
99.4
total cholesterol measurement
7
98.8
bilirubin measurement
4
90
apolipoprotein B measurement
3
87
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GEM interacting protein
VGNC:3635
455880
Macaque
GEM interacting protein
720380
Mouse
MGI:1926066
78816
Rat
RGD:1565577
306357
Dog
GEM interacting protein
VGNC:41289
484801
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GEM interacting protein
Macaque
GEM interacting protein
Mouse
Rat
Dog
GEM interacting protein
Publication Statistics
PubMed Score 27.83
PubMed score by year
PubTator Score 5.62
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title