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Tbio
PIPOX
Peroxisomal sarcosine oxidase

Protein Summary
Description
Metabolizes sarcosine, L-pipecolic acid and L-proline.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323372
  • ENSP00000317721
  • ENSG00000179761

Symbol
  • LPIPOX
  • PSO
  • LPIPOX
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
cell type or tissue
0.74
PubMedID
0.71
gene perturbation
0.66
transcription factor binding site profile
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.55   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.55   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (125)
ELP4
Tbio
Novelty:  0.03734233
p_int:  0.999999933
p_ni:  6.7e-8
Score:  0.933
Data Source:  BioPlex,STRINGDB
ELP5
Tbio
Novelty:  0.07212185
p_int:  0.999998123
p_ni:  2.39e-7
p_wrong:  0.000001638
Score:  0.857
Data Source:  BioPlex,STRINGDB
ZNF217
Tbio
Family:  TF
Novelty:  0.01313576
p_int:  0.999879696
p_ni:  0.000120274
p_wrong:  3e-8
Score:  0.587
Data Source:  BioPlex,STRINGDB
ELP6
Tbio
Novelty:  0.01229878
p_int:  0.999469181
p_ni:  0.000530819
Score:  0.864
Data Source:  BioPlex,STRINGDB
NAPG
Tbio
Novelty:  0.02295985
p_int:  0.998580032
p_ni:  0.001419874
p_wrong:  9.4e-8
Score:  0.163
Data Source:  BioPlex,STRINGDB
FKBP5
Tchem
Family:  Enzyme
Novelty:  0.00214511
p_int:  0.991051861
p_ni:  0.008948137
p_wrong:  2e-9
Score:  0.183
Data Source:  BioPlex,STRINGDB
HAO2
Tchem
Family:  Enzyme
Novelty:  0.03029536
Score:  0.985
Data Source:  STRINGDB
AGXT
Tbio
Family:  Enzyme
Novelty:  0.00267512
Score:  0.983
Data Source:  STRINGDB
HAO1
Tclin
Family:  Enzyme
Novelty:  0.00054723
Score:  0.972
Data Source:  STRINGDB
LONP2
Tbio
Family:  Enzyme
Novelty:  0.04499043
Score:  0.97
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Lysine catabolism (R-HSA-71064)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Lysine catabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Peroxisomal protein import
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Lysine catabolism
Metabolism
Metabolism of amino acids and derivatives
Peroxisomal protein import
Protein localization
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
3
3
98
reticulocyte count
4
3
4
94
reticulocyte measurement
2
2
2
89.1
mean corpuscular hemoglobin concentration
3
3
3
88.4
HbA1c measurement
3
3
4
86.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
98
reticulocyte count
4
94
reticulocyte measurement
2
89.1
mean corpuscular hemoglobin concentration
3
88.4
HbA1c measurement
4
86.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pipecolic acid and sarcosine oxidase
VGNC:9525
454541
Macaque
pipecolic acid and sarcosine oxidase
711090
Mouse
MGI:1197006
19193
Rat
RGD:1311347
303272
Dog
pipecolic acid and sarcosine oxidase
VGNC:44578
491177
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pipecolic acid and sarcosine oxidase
Macaque
pipecolic acid and sarcosine oxidase
Mouse
Rat
Dog
pipecolic acid and sarcosine oxidase
Publication Statistics
PubMed Score 24.55
PubMed score by year
PubTator Score 43.56
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title