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Tclin
CACNA1I
Voltage-dependent T-type calcium channel subunit alpha-1I

Protein Summary
Description
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Gates in voltage ranges similar to, but higher than alpha 1G or alpha 1H (By simil ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000401624
  • ENSP00000383887
  • ENSG00000100346
  • ENST00000402142
  • ENSP00000385019
  • ENST00000404898
  • ENSP00000384093
  • ENST00000407673
  • ENSP00000385680

Symbol
  • KIAA1120
  • Cav3.3
  • ca(v)3.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.84
protein domain
0.73
virus perturbation
0.64
small molecule perturbation
0.61
tissue
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.82   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 90   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.82   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 250
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (70)
1 – 10 of 70
NCAM1
Tbio
Novelty:  0.00020994
Score:  0.904
Data Source:  Reactome,STRINGDB
CACNA1G
Tclin
Family:  IC
Novelty:  0.00380386
Score:  0.824
Data Source:  STRINGDB
CACNA1H
Tclin
Family:  IC
Novelty:  0.00342394
Score:  0.821
Data Source:  STRINGDB
NOS1
Tchem
Family:  Enzyme
Novelty:  0.00032064
Score:  0.811
Data Source:  STRINGDB
CAV3
Tbio
Novelty:  0.00190092
Score:  0.795
Data Source:  STRINGDB
CALML4
Tdark
Novelty:  0.44764047
Score:  0.731
Data Source:  STRINGDB
KCND2
Tclin
Family:  IC
Novelty:  0.00297203
Score:  0.713
Data Source:  STRINGDB
CALM1
Tclin
Novelty:  0.00308267
Score:  0.691
Data Source:  STRINGDB
CACNB2
Tbio
Family:  IC
Novelty:  0.01745218
Score:  0.682
Data Source:  STRINGDB
CALML5
Tbio
Novelty:  0.03240679
Score:  0.673
Data Source:  STRINGDB
Pathways (13)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
NCAM signaling for neurite out-growth
Reactome
NCAM1 interactions
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
NCAM signaling for neurite out-growth
NCAM1 interactions
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
4
4
3
5.6
85.6
alkaline phosphatase measurement
1
1
1
78.9
9
8
4
1.1
75.2
intelligence
4
9
8
5.7
71.6
reticulocyte measurement
2
1
2
61.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
5.6
85.6
alkaline phosphatase measurement
1
78.9
4
1.1
75.2
intelligence
8
5.7
71.6
reticulocyte measurement
2
61.4
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calcium voltage-gated channel subunit alpha1 I
458848
Mouse
MGI:2178051
239556
Dog
calcium voltage-gated channel subunit alpha1 I
VGNC:38639
481243
Horse
calcium voltage-gated channel subunit alpha1 I
VGNC:49307
100070365
Cow
calcium voltage-gated channel subunit alpha1 I [Source:HGNC Symbol;Acc:HGNC:1396]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calcium voltage-gated channel subunit alpha1 I
Mouse
Dog
calcium voltage-gated channel subunit alpha1 I
Horse
calcium voltage-gated channel subunit alpha1 I
Cow
calcium voltage-gated channel subunit alpha1 I [Source:HGNC Symbol;Acc:HGNC:1396]
Publication Statistics
PubMed Score 121.82
PubMed score by year
PubTator Score 28.57
PubTator score by year
Patents
Patents by year