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Tclin
CACNA1I
Voltage-dependent T-type calcium channel subunit alpha-1I

Protein Summary
Description
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Gates in voltage ranges similar to, but higher than alpha 1G or alpha 1H (By simil ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000401624
  • ENSP00000383887
  • ENSG00000100346
  • ENST00000402142
  • ENSP00000385019
  • ENST00000404898
  • ENSP00000384093
  • ENST00000407673
  • ENSP00000385680

Symbol
  • KIAA1120
  • Cav3.3
  • ca(v)3.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.84
protein domain
0.73
virus perturbation
0.64
small molecule perturbation
0.61
tissue
0.56


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.17   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 90   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.17   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 250
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6