You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
HMG20B
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related

Protein Summary
Description
Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333651
  • ENSP00000328269
  • ENSG00000064961

Symbol
  • BRAF35
  • HMGX2
  • HMGXB2
  • SMARCE1R
  • SOXL
  • HMGX2
  • BRAF25
  • BRAF35
  • HMGXB2
  • PP7706
  • pp8857
  • SMARCE1r
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
histone modification site profile
0.83
protein complex
0.74
biological process
0.72
transcription factor
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.57   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 274   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.57   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 274   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (65)
HMG20A
Tbio
Family:  TF
Novelty:  0.11994252
p_int:  1
Score:  0.831
Data Source:  BioPlex,STRINGDB
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
p_int:  0.999999986
p_ni:  1.4e-8
Score:  0.981
Data Source:  BioPlex,STRINGDB
PHF21A
Tbio
Family:  Epigenetic
Novelty:  0.05904464
p_int:  0.999999914
p_ni:  8.6e-8
Score:  0.996
Data Source:  BioPlex,STRINGDB
GSE1
Tdark
Novelty:  0.04331197
p_int:  0.999999866
p_ni:  1.33e-7
p_wrong:  1e-9
Score:  0.879
Data Source:  BioPlex,STRINGDB
RCOR2
Tbio
Family:  TF
Novelty:  0.17728151
p_int:  0.999987936
p_ni:  0.000012064
Score:  0.9
Data Source:  BioPlex,STRINGDB
RCOR3
Tdark
Family:  TF
Novelty:  0.18886215
p_int:  0.99981279
p_ni:  0.00018721
Score:  0.888
Data Source:  BioPlex,STRINGDB
RCOR1
Tbio
Family:  TF
Novelty:  0.00644648
p_int:  0.99968536
p_ni:  0.00031464
Score:  0.993
Data Source:  BioPlex,STRINGDB
LLGL2
Tbio
Novelty:  0.07084531
p_int:  0.972986468
p_ni:  0.026870714
p_wrong:  0.000142818
Score:  0.67
Data Source:  BioPlex,STRINGDB
KDM1A
Tchem
Family:  Epigenetic
Novelty:  0.00142673
p_int:  0.972797653
p_ni:  0.027202347
Score:  0.991
Data Source:  BioPlex,STRINGDB
HDAC2
Tclin
Family:  Epigenetic
Novelty:  0.0011024
p_int:  0.960757064
p_ni:  0.039242936
Score:  0.986
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
HDACs deacetylate histones
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Factors involved in megakaryocyte development and platelet production
HDACs deacetylate histones
Hemostasis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
1
2
62.6
1
1
0
1.5
39.6
reticulocyte measurement
1
1
1
7.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
62.6
0
1.5
39.6
reticulocyte measurement
1
7.4
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
high mobility group 20B
VGNC:2357
735779
Mouse
MGI:1341190
15353
Rat
RGD:1309235
362825
Dog
high mobility group 20B
VGNC:41708
612026
Opossum
high mobility group 20B
100010881
Species
Name
OMA
EggNOG
Inparanoid
Chimp
high mobility group 20B
Mouse
Rat
Dog
high mobility group 20B
Opossum
high mobility group 20B
Publication Statistics
PubMed Score 17.57
PubMed score by year
PubTator Score 8.61
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title