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Tbio
IFNK
Interferon kappa

Protein Summary
Description
May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon-stimulated response element signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparin. This gene encodes a member of the type I interferon family. Type I interferons are a group of related glycoproteins that play an important role in host defenses against viral infections. This protein is expressed in keratinocytes and the gene is found on chromosome 9, adjacent to the type I interferon cluster. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276943
  • ENSP00000276943
  • ENSG00000147896

Symbol
  • IFNT1
  • INFE1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.84
cell type or tissue
0.82
cell line
0.67
tissue sample
0.6
tissue
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.41   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 81   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.41   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (4)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
JAK-STAT signaling pathway
KEGG
Cytokine-cytokine receptor interaction
KEGG
RIG-I-like receptor signaling pathway
Name
Explore in Pharos
Explore in Source
JAK-STAT signaling pathway
Cytokine-cytokine receptor interaction
RIG-I-like receptor signaling pathway
Gene Ontology Terms (19)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (60)
1 – 10 of 60
IFNAR1
Tclin
Novelty: 0.00175488
Score: 0.898
Data Source: STRINGDB
IFNAR2
Tclin
Novelty: 0.00453303
Score: 0.859
Data Source: STRINGDB
MOB3B
Tbio
Family: Enzyme
Novelty: 0.16818316
Score: 0.813
Data Source: STRINGDB
IL10RB
Tbio
Novelty: 0.00880915
Score: 0.722
Data Source: STRINGDB
IFNGR1
Tbio
Novelty: 0.00417244
Score: 0.714
Data Source: STRINGDB
IFNGR2
Tbio
Novelty: 0.01304474
Score: 0.714
Data Source: STRINGDB
IFNLR1
Tbio
Novelty: 0.01990628
Score: 0.686
Data Source: STRINGDB
IL20RA
Tbio
Novelty: 0.02416816
Score: 0.663
Data Source: STRINGDB
NDUFB6
Tclin
Family: Enzyme
Novelty: 0.075245
Score: 0.662
Data Source: STRINGDB
IL12RB1
Tbio
Novelty: 0.00398741
Score: 0.636
Data Source: STRINGDB
Publication Statistics
PubMed Score  18.41

PubMed score by year
PubTator Score  20.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer